Гелан тетрасахаридна незасићено глукуронилна хидролаза
Gelan tetrasaharidna nezasićeno glukuronilna hidrolaza (EC 3.2.1.179, UGL, hidrolaza nezasićenog glukuronila) je enzim sa sistematskim imenom beta-D-4-dezoksi-Delta4-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alfa-L-Rhap-(1->3)-beta-D-Glcp beta-D-4-dezoksi-Delta4-GlcAp hidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Gelan tetrasaharidna nezasićeno glukuronilna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.1.179 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- beta-D-4-dezoksi-Delta4-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alfa-L-Rhap-(1->3)-beta-D-Glcp + H 2O
5-dehidro-4-dezoksi-D-glukuronat + beta-D-Glcp-(1->4)-alfa-L-Rhap-(1->3)-beta-D-Glcp
Ovaj enzim odvaja 4-dezoksi-4(5)-nezasićene D-glucuronske kiselina sa oligosaharida koje formiraju polisaharidne lijaze.
Reference
уреди- ^ Itoh, T., Akao, S., Hashimoto, W., Mikami, B. and Murata, K. (2004). „Crystal structure of unsaturated glucuronyl hydrolase, responsible for the degradation of glycosaminoglycan, from Bacillus sp. GL1 at 1.8 Å resolution”. J. Biol. Chem. 279: 31804—31812. PMID 15148314.
- ^ Hashimoto, W., Kobayashi, E., Nankai, H., Sato, N., Miya, T., Kawai, S. and Murata, K. (1999). „Unsaturated glucuronyl hydrolase of Bacillus sp. GL1: novel enzyme prerequisite for metabolism of unsaturated oligosaccharides produced by polysaccharide lyases”. Arch. Biochem. Biophys. 368: 367—374. PMID 10441389.
- ^ Itoh, T., Hashimoto, W., Mikami, B. and Murata, K. (2006). „Substrate recognition by unsaturated glucuronyl hydrolase from Bacillus sp. GL1”. Biochem. Biophys. Res. Commun. 344: 253—262. PMID 16630576.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Gellan+tetrasaccharide+unsaturated+glucuronyl+hydrolase на US National Library of Medicine Medical Subject Headings (MeSH)
