Хомосерин дехидрогеназа
Homoserin dehidrogenaza (EC 1.1.1.3, homoserinska dehidrogenaza, HSDH, HSD) je enzim sa sistematskim imenom L-homoserin:NAD(P)+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Homoserin dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.3 | ||||||||
| CAS broj | 9028-13-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- L-homoserin + NAD(P)+ L-aspartat 4-semialdehid + NAD(P)H + H+
Enzim kvasca deluje najbrže sa NAD+, dok enzim iz neurospora koristi NADP+. Enzim iz Escherichia coli je multi-funkcionalni protein, koji takođe katalizuje reakciju aspartat kinaze (EC 2.7.2.4).
Reference
уреди- ^ Black, S. & Wright, N.G. (1955). „Homoserine dehydrogenase”. J. Biol. Chem. 213: 51—60. PMID 14353905.
- ^ Starnes, W.L., Munk, P., Maul, S.B., Cunningham, G.N., Cox, D.J. and Shive, W. (1972). „Threonine-sensitive aspartokinase-homoserine dehydrogenase complex, amino acid composition, molecular weight, and subunit composition of the complex”. Biochemistry. 11: 677—687. PMID 4551091.
- ^ Véron, M., Falcoz-Kelly, F. and Cohen, G.N. (1972). „The threonine-sensitive homoserine dehydrogenase and aspartokinase activities of Escherichia coli K12. The two catalytic activities are carried by two independent regions of the polypeptide chain”. Eur. J. Biochem. 28: 520—527. PMID 4562990.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Homoserine+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)
