Изопеницилин-Н Н-ацилтрансфераза
Izopenicilin-N N-aciltransferaza (EC 2.3.1.164, acil-koenzim A:izopenicilin N aciltransferaza, izopenicilin N:acil-KoA: aciltransferaza) je enzim sa sistematskim imenom acil-KoA:izopenicilin N N-aciltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
Izopenicilin-N N-aciltransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.3.1.164 | ||||||||
CAS broj | 54576-90-8 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
|
- fenilacetil-KoA + izopenicilin N +H2O KoA + penicilin G + L-2-aminoheksandioat
Ova reakcija se odvija u dva stupnja.
Reference
уреди- ^ Tobin, M.B., Fleming, M.D., Skatrud, P.L. and Miller, J.R. (1990). „Molecular characterization of the acyl-coenzyme A:isopenicillin N acyltransferase gene (penDE) from Penicillium chrysogenum and Aspergillus nidulans and activity of recombinant enzyme in Escherichia coli”. J. Bacteriol. 172: 5908—5914. PMID 2120195.
- ^ Aplin, R.T., Baldwin, J.E., Roach, P.L., Robinson, C.V. and Schofield, C.J. (1993). „Investigations into the post-translational modification and mechanism of isopenicillin N:acyl-CoA acyltransferase using electrospray mass spectrometry”. Biochem. J. 294: 357—363. PMID 8396910.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Isopenicillin-N+N-acyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)