Кармустин

Karmustin
Nazivi
	IUPAC naziv 1,3-Bis(2-hloroetil)-1-nitrozoureja
	Drugi nazivi N,N’-Bis(2-hloroetil)-N-nitrozo-ureja
Identifikacija
CAS broj	154-93-8 ;
3D model (Jmol)	interaktivna slika;
ChEBI	CHEBI:3423 ;
ChemSpider	2480 ;
DrugBank	DB00262 ;
ECHA InfoCard	100.005.309
EC broj	205-838-2
KEGG	D00254 ;
MeSH	Carmustine
PubChem C ID	2578;
RTECS	YS2625000
UNII	U68WG3173Y ;
UN broj	2811
	SMILES ; ClCCNC(=O)N(CCCl)N=O; ; ; ; ;
Svojstva
Hemijska formula	C5H9Cl2N3O2
Molarna masa	214,05 g·mol−1
Agregatno stanje	Orange crystals-lat
Miris	Bez mirisa
Tačka topljenja	30 °C (86 °F; 303 K)
log P	1,375
Kiselost (pKa)	10,194
Baznost (pKb)	3,803
Farmakologija
Načini upotrebe	Intravenozno
	Farmakokinetika:
Bioraspoloživost	5–28%
Vezivanje za proteine	80%
Metabolizam	Hepatički
Poluvreme eliminacije	15–30 min
Izlučivanje	Renalno; Respiratorno;
Legalni status	℞ (Само на рецепат);
Opasnosti
GHS signalna reč	Opsasnost
GHS opis opasnosti	H300, H350, H360
GHS mere predostrožnosti	P301+310, P308+313
EU klasifikacija (DSD)	T+
R-oznake	R45, R46, R60, R61, R28
S-oznake	S22, S36/37/39, S45
	Letalna doza ili koncentracija (LD, LC):
LD50 (LD50)	20 mg kg−1 (oralno, pacov)
Srodna jedinjenja
Srodne ureje	Dimetilureja
Srodna jedinjenja	Noksitiolin; 1,1,3,3-Tetrametilguanidin; Metformin; Alantoinska kiselina; Buformin;
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

Karmustin ili BCNU (bis-hloroetilnitrozoureja) je β-hloro-nitrozourejno jedinjenje strodno sa azotnim iperitom, koje se koristi kao alkilirajući agens u hemoterapiji.^[5]^[6] Kao dialkilirajući agens, BCNU ima sposobnost formiranja veza između DNK lanaca, čime se onemogućava DNK replikacija i DNK transkripcija.

It has the appearance of an orange-yellow solid.

Carmustine for injection is marketed under the name BiCNU by Bristol-Myers Squibb. In India, carmustine is marketed under the name Carustine by Curacell Biotech.

Reference

^ „Carmustine - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 25. 3. 2005. Identification. Приступљено 11. 4. 2012.
^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682.
^ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. 36 (Database issue): D901—6. PMID 18048412.

Spoljašnje veze

MedlinePlus DrugInfo medmaster-a682060
BiCNU (package insert; U.S.)

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] „Carmustine - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 25. 3. 2005. Identification. Приступљено 11. 4. 2012.

[2] Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[3] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[4] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[5] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682.

[6] Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. 36 (Database issue): D901—6. PMID 18048412.

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