Каспаза-6
Kaspaza-6 (EC 3.4.22.59, CASP-6, apoptotička proteaza Mch-2, Mch2) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Kaspaza-6 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.59 | ||||||||
| CAS broj | 182372-15-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Neophodno je prisustvo Asp ostatka u P1 poziciji. Preferentno dolazi do razlaganja sekvence Val-Glu-His-Asp-
Kaspaza-6 je efektor/izvršilac kaspaze, kao što su i kaspaza-3 (EC 3.4.22.56) i kaspaza-7 (EC 3.4.22.60).
Reference
уреди- ^ Cowling, V. & Downward, J. (2002). „Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain”. Cell Death Differ. 9: 1046—1056. PMID 12232792.
- ^ Chang, H.Y. & Yang, X. (2000). „Proteases for cell suicide: functions and regulation of caspases”. Microbiol. Mol. Biol. Rev. 64: 821—846. PMID 11104820.
- ^ Kang, B.H., Ko, E., Kwon, O.K. and Choi, K.Y. (2002). „The structure of procaspase 6 is similar to that of active mature caspase 6”. Biochem. J. 364: 629—634. PMID 12049625.
- ^ Lee, S.C., Chan, J., Clement, M.V. and Pervaiz, S. (2006). „Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop”. Proteomics. 6: 2386—2394. PMID 16518869.
- ^ MacLachlan, T.K. & El-Deiry, W.S. (2002). „Apoptotic threshold is lowered by p53 transactivation of caspase-6”. Proc. Natl. Acad. Sci. USA. 99: 9492—9497. PMID 12089322.
- ^ Takahashi, A., Alnemri, E.S., Lazebnik, Y.A., Fernandes-Alnemri, T., Litwack, G., Moir, R.D., Goldman, R.D., Poirier, G.G., Kaufmann, S.H. and Earnshaw, W.C. (1996). „Cleavage of lamin A by Mch2α but not CPP32: multiple interleukin 1β-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis”. Proc. Natl. Acad. Sci. USA. 93: 8395—8400. PMID 8710882.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
