Коагулациони фактор XИа
Koagulacioni faktor XIa (EC 3.4.21.27, krvno koagulacioni faktor XIa, aktivirani krvno koagulacioni faktor XI, aktivirani plazmatični tromboplastinski prethodnik) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Koagulacioni faktor XIa | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 3.4.21.27 | ||||||||
| CAS broj | 37203-61-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Selektivno razlaganje Arg-Ala i Arg-Val veza u faktoru IX čime se formira faktor IXa
Ovaj enzim je jedan od krvnih koagulacionih faktora u peptidaza family S1 (tripsinskoj familiji).
Reference
уреди- ^ Kurachi, K. & Davie, E.W. (1981). „Human factor XI (plasma thromboplastin antecedent)”. Methods Enzymol. 80: 211—220.
- ^ Cho, K.; Tanaka, T.; Cook, R.R.; Kisiel, W.; Fujikawa, K.; Kurachi, K. & Powers, J.C. (1984). „Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates”. Biochemistry. 23: 644—650. PMID 6370301.
- ^ Fujikawa, K.; Chung, D.W.; Hendrickson, L.E. & Davie, E.W. (1986). „Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein”. Biochemistry. 25: 2417—2424. PMID 3636155.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Coagulation+factor+XIa на US National Library of Medicine Medical Subject Headings (MeSH)
