L-метионин (С)-С-оксид редуктаза
L-metionin (S)-S-oksid reduktaza (EC 1.8.4.13, fSMsr, metil sulfoksid reduktaza I i II, acetilmetionin sulfoksidna reduktaza, metionin sulfoksidna reduktaza, L-metionin:oksidovani-tioredoksin S-oksidoreduktaza, metionin-S-oksidna reduktaza, free-metionin (S)-S-oksidna reduktaza) je enzim sa sistematskim imenom L-metionin:tioredoksin-disulfid S-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
L-metionin (S)-S-oksid reduktaza | |||||||||
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Identifikatori | |||||||||
EC broj | 1.8.4.13 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- L-metionin + tioredoksin disulfid +H2O L-metionin (S)-S-oksid + tioredoksin
Za rad ovog enzima je neophodan NADPH. Reakcija se odvija u reverznom smeru.
Reference
уреди- ^ Black, S., Harte, E.M., Hudson, B. and Wartofsky, L. (1960). „A specific enzymatic reduction of L-(-)methionine sulfoxide and a related nonspecific reduction of diulfides”. J. Biol. Chem. 235: 2910—2916.
- ^ Ejiri, S.-I., Weissbach, H. and Brot, N. (1979). „Reduction of methionine sulfoxide to methionine by Escherichia coli”. J. Bacteriol. 139: 161—164. PMID 37234.
- ^ Ejiri, S.-I., Weissbach, H. and Brot, N. (1980). „The purification of methionine sulfoxide reductase from Escherichia coli”. Anal. Biochem. 102: 393—398. PMID 6999943.
- ^ Weissbach, H., Resnick, L. and Brot, N. (2005). „Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage”. Biochim. Biophys. Acta. 1703: 203—212. PMID 15680228.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- L-methionine+(S)-S-oxide+reductase на US National Library of Medicine Medical Subject Headings (MeSH)