Леукоцитна еластаза

Leukocitna elastaza (EC 3.4.21.37, lizozomalna elastaza, neutrofilna elastaza, polimorfonuklearna leukocitna elastaza, elastaza, elaszim, serinska elastaza, lizozomalna elastaza, granulocitna elastaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Leukocitna elastaza
Identifikatori
EC broj3.4.21.37
CAS broj2594837
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum
Hidroliza proteina, uključujući elastin. Preferentno odvajanje Val- > Ala-

Ovaj enzim se razlikuje od pankreasne elastaze po specifičnosti na sintetičim supstratima i po senzitivnosti na inhibitore.

Reference

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  1. ^ Barrett, A.J. (1981). „Leukocyte elastase”. Methods Enzymol. 80: 581—588. PMID 7043201. 
  2. ^ Harper, J.W., Cook, R.R., Roberts, C.J., McLaughlin, B.J. and Powers, J.C. (1984). „Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II, bovine chymotrypsin Aα, and Staphylococcus aureus' protease V-8 using tripeptide thiobenzyl ester substrates”. Biochemistry. 23: 2995—3002. PMID 6380580. 
  3. ^ Stein, R.L., Strimpler, A.M., Hori, H. and Powers, J.C. (1987). „Catalysis by human leukocyte elastase: mechanistic insights into specificity requirements”. Biochemistry. 26: 1301—1305. PMID 3646070. 
  4. ^ Bode, W., Meyer, E., Jr. and Powers, J.C. (1989). „Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors”. Biochemistry. 28: 1951—1963. PMID 2655701. 

Literatura

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Spoljašnje veze

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