Нардилизин
Nardilizin (EC 3.4.24.61, N-arginin dibazna konvertaza, NRD-konvertaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
Nardilizin | |||||||||
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Identifikatori | |||||||||
EC broj | 3.4.24.61 | ||||||||
CAS broj | 292850-69-2 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Hidroliza polipeptida, preferentno u -Xaa-Arg-Lys-, i u manjoj meri -Arg-Arg-Xaa-, pri čemu Xaa nije Arg ili Lys
Ovaj enzim je prisutan u mozgu i testisima pacova.
Reference
уреди- ^ Gomez, S., Gluschankof, P., Morel, A. and Cohen, P. (1985). „The somatostatin-28 convertase of rat brain cortex is associated with secretory granule membranes”. J. Biol. Chem. 260: 10541—10545. PMID 3897221.
- ^ Gluschankof, P., Gomez, S., Morel, A. and Cohen, P. (1987). „Enzymes that process somatostatin precursors. A novel endoprotease that cleaves before the arginine-lysine doublet is involved in somatostatin-28 convertase activity of rat brain cortex”. J. Biol. Chem. 262: 9615—9620. PMID 2885328.
- ^ Chesneau, V., Pierotti, A.R., Barré, N., Créminon, C., Tougard, C. and Cohen, P. (1994). „Isolation and characterization of a dibasic selective metalloendopeptidase from rat testes that cleaves at the amino terminus of arginine residues”. J. Biol. Chem. 269: 2056—2061. PMID 8294457.
- ^ Pierotti, A.R., Prat, A., Chesneau, V., Gaudoux, F., Leseney, A.-M., Foulon, T. and Cohen, P. (1994). „N-Arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes”. Proc. Natl. Acad. Sci. USA. 91: 6078—6082. PMID 8016118.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Nardilysin на US National Library of Medicine Medical Subject Headings (MeSH)