Termolizin (EC 3.4.24.27, Bacillus thermoproteolyticus neutralna proteinaza, termoaza, termoaza Y10, TLN) je enzim.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

Termolizin
Identifikatori
EC broj3.4.24.27
CAS broj9073-78-3
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum
Preferentno razlaganje: -Leu > -Phe

Ova termostabilna ekstracelularna metaloendopeptidaza sadrži četiri jona kalcijuma.

Reference

уреди
  1. ^ Ohta, Y. Ogura, Y. and Wada, A. (1966). „Thermostable protease from thermophilic bacteria. I. Thermostability, physicochemical properties, and amino acid composition”. J. Biol. Chem. 241: 5919—5925. PMID 5954368. 
  2. ^ Morihara, K., Tsuzuki, H. and Oka, T. (1968). „Comparison of the specificities of various neutral proteinases from microorganisms”. Arch. Biochem. Biophys. 123: 572—588. PMID 4967801. 
  3. ^ Latt, S. (1969). „A., Holmquist, B. and Vallee, B. L. Thermolysin: a zinc metalloenzyme”. Biochem. Biophys. Res. Commun. 37: 333—339. PMID 5823940. 
  4. ^ Desmazeaud, M. (1971). „J. and Hermier, J. H. Spécificité de la protéase neutre de Micrococcus caseolyticus”. Eur. J. Biochem. 19: 51—55. PMID 5551628. 
  5. ^ Morihara, K. & Tsuzuki, H. (1971). „Comparative study of various neutral proteinases from microorganisms: specificity with oligopeptides”. Arch. Biochem. Biophys. 146: 291—296. PMID 5004124. 
  6. ^ Titani, K., Hermodson, M. (1972). „A., Ericson, L. H., Walsh, K. A. and Neurath, H. Amino-acid sequence of thermolysin”. Nature New Biol. 238: 35—37. 
  7. ^ Matthews, B. (1988). „W. Structural basis of the action of thermolysin and related zinc peptidases”. Acc. Chem. Res. 21: 333—340. 

Literatura

уреди

Spoljašnje veze

уреди
  • Thermolysin на US National Library of Medicine Medical Subject Headings (MeSH)