Тимин-ДНК гликозилаза
Timin-DNK glikozilaza (EC 3.2.2.29, za neusklađenost specifična timin-DNK glikozilaza, za neusklađenost specifična timin-DNK N-glikozilaza, hTDG, hsTDG, TDG, timinska DNK glikozilaza, G/T glikozilaza, uracil/timin DNK glikozilaza, T:G za neusklađenost specifična timidin-DNK glikozilaza, G:T za neusklađenost specifična timinska DNK-glikozilaza) je enzim sa sistematskim imenom timin-DNK dezoksiribohidrolaza (otpuštanje timina).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
Timin-DNK glikozilaza | |||||||||
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Identifikatori | |||||||||
EC broj | 3.2.2.29 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- specifična hidroliza neusklađene dvolančane DNK i polinukleotida čime se oslobađa timin
Zimin-DNK glikozilaza je deo mehanizma za popravku DNK.
Reference
уреди- ^ Waters, T.R. & Swann, P.F. (2000). „Thymine-DNA glycosylase and G to A transition mutations at CpG sites”. Mutat. Res. 462: 137—147. PMID 10767625.
- ^ Neddermann, P. & Jiricny, J. (1993). „The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells”. J. Biol. Chem. 268: 21218—21224. PMID 8407958.
- ^ Waters, T.R. & Swann, P.F. (1998). „Kinetics of the action of thymine DNA glycosylase”. J. Biol. Chem. 273: 20007—20014. PMID 9685338.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Thymine-DNA+glycosylase на US National Library of Medicine Medical Subject Headings (MeSH)