УДП-2-ацетамидо-2-дезокси-рибо-хексулуронат аминотрансфераза
UDP-2-acetamido-2-dezoksi-ribo-heksuluronat aminotransferaza (EC 2.6.1.98, WbpE, WlbC) je enzim sa sistematskim imenom UDP-2-acetamido-3-amino-2,3-didezoksi-alfa-D-glukuronat:2-oksoglutarat aminotransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| UDP-2-acetamido-2-dezoksi-ribo-heksuluronat aminotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.6.1.98 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-2-acetamido-3-amino-2,3-didezoksi-alfa-D-glukuronat + 2-oksoglutarat UDP-2-acetamido-2-dezoksi-alfa-D-ribo-heks-3-uluronat + L-glutamat
Ovaj enzim je piridoksal 5'-fosfatni protein. On učestvujeu u biosintezi UDP-alfa-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-didezoksi-alfa-D-manuronske kiseline).
Reference
уреди- ^ Westman, E.L., McNally, D.J., Charchoglyan, A., Brewer, D., Field, R.A. and Lam, J.S. (2009). „Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa”. J. Biol. Chem. 284: 11854—11862. PMID 19282284.
- ^ Larkin, A. & Imperiali, B. (2009). „Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1”. Biochemistry. 48: 5446—5455. PMID 19348502.
- ^ Larkin, A., Olivier, N.B. and Imperiali, B. (2010). „Structural analysis of WbpE from Pseudomonas aeruginosa PAO1: a nucleotide sugar aminotransferase involved in O-antigen assembly”. Biochemistry. 49: 7227—7237. PMID 20604544.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- UDP-2-acetamido-2-deoxy-ribo-hexuluronate+aminotransferase на US National Library of Medicine Medical Subject Headings (MeSH)
