7a-hidroksisteroid dehidrogenaza
7a-hidroksisteroid dehidrogenaza (EC 1.1.1.159, 7alfa-hidroksi steroidna dehidrogenaza, 7alfa-HSDH) je enzim sa sistematskim imenom 7alfa-hidroksisteroid:NAD+ 7-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 7a-hidroksisteroid dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.159 | ||||||||
| CAS broj | 39361-64-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- holat + NAD+ 3alfa,12alfa-dihidroksi-7-okso-5beta-holan-24-oat + NADH + H+
7a-Hidroksisteroidna dehidrogenaza katalizuje oksidaciju 7alfa-hidroksi grupa žučne kiseline i alkohola u njihovim slobodnim i konjugovanim formama. Bacteroides fragilis i Clostridium enzimi takođe mogu da koriste NADP+.
Reference
uredi- ^ Haslewood, E.S. & Haslewood, G.A.D. (1976). „The specificity of a 7α-hydroxy steroid dehydrogenase from Escherichia coli”. Biochem. J. 157: 207—210. PMID 786279.
- ^ Macdonald, I.A. & Roach, P.D. (1981). „Bile induction of 7α- and 7β-hydroxysteroid dehydrogenases in Clostridium absonum”. Biochim. Biophys. Acta. 665: 262—269. PMID 6945134.
- ^ Macdonald, I.A., Williams, C.N. and Mahony, D.E. (1973). „7α-Hydroxysteroid dehydrogenase from Escherichia coli B: preliminary studies”. Biochim. Biophys. Acta. 309: 243—253. PMID 4581498.
- ^ Macdonald, I.A., Williams, C.N., Mahony, D.E. and Christie, W.M. (1975). „NAD- and NADP-dependent 7α-hydroxysteroid dehydrogenases from Bacteroides fragilis”. Biochim. Biophys. Acta. 384: 12—24. PMID 236764.
Literatura
uredi- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
uredi- 7alpha-hydroxysteroid+dehydrogenase na US National Library of Medicine Medical Subject Headings (MeSH)
