D-alanin—(R)-laktat ligaza
D-alanin—(R)-laktat ligaza (EC 6.1.2.1, VanA, VanB, VanD) je enzim sa sistematskim imenom D-alanin:(R)-laktat ligaza (formira ADP).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| D-alanin—(R)-laktat ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.1.2.1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Produkt ovog enzim može da bude inkorporisan u peptidoglikan pentapeptid umesto u uobičajeni D-alanil-D-alanin dipeptid.
Reference
uredi- ^ Bugg, T.D., Wright, G.D., Dutka-Malen, S., Arthur, M., Courvalin, P. and Walsh, C.T. (1991). „Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA”. Biochemistry. 30: 10408—10415. PMID 1931965.
- ^ Meziane-Cherif, D., Badet-Denisot, M.A., Evers, S., Courvalin, P. and Badet, B. (1994). „Purification and characterization of the VanB ligase associated with type B vancomycin resistance in Enterococcus faecalis V583”. FEBS Lett. 354: 140—142. PMID 7957913.
- ^ Perichon, B., Reynolds, P. and Courvalin, P. (1997). „VanD-type glycopeptide-resistant Enterococcus faecium BM4339”. Antimicrob. Agents Chemother. 41: 2016—2018. PMID 9303405.
Literatura
uredi- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
uredi- D-alanine-(R)-lactate+ligase na US National Library of Medicine Medical Subject Headings (MeSH)
