Fosfo-N-acetilmuramoil-pentapeptid-transferaza
Fosfo-N-acetilmuramoil-pentapeptid-transferaza (EC 2.7.8.13, MraY transferaza, UDP-MurNAc-L-Ala-D-gama-Glu-L-Lys-D-Ala-D-Ala:C55-izoprenoid alkoholna transferaza, UDP-MurNAc-Ala-gamaDGlu-Lys-DAla-DAla:undekaprenilfosfat transferaza, fosfo-N-acetilmuramoil pentapeptidna translokaza, fosfo-MurNAc-pentapeptidna transferaza, fosfo-NAc-muramoil-pentapeptidna translokaza (UMP), fosfoacetilmuramoilpentapeptidna translokaza, fosfoacetilmuramoilpentapeptidtransferaza) je enzim sa sistematskim imenom UDP-MurAc(oil-L-Ala-gama-D-Glu-L-Lis-D-Ala-D-Ala):undekaprenil-fosfat fosfo-N-acetilmuramoil-pentapeptid-transferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fosfo-N-acetilmuramoil-pentapeptid-transferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.8.13 | ||||||||
| CAS broj | 9068-50-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- UDP-Mur2Ac(oil-L-Ala-gama-D-Glu-L-Lys-D-Ala-D-Ala) + undekaprenil fosfat UMP + Mur2Ac(oil-L-Ala-gama-D-Glu-L-Lys-D-Ala-D-Ala)-difosfoundekaprenol
Kod Gram-negativnih i pojedinih Gram-pozitivnih organizama L-lizin je zamenjen meso-2,6-diaminoheptanedioatom.
Reference
uredi- ^ Heydanek, M.G., Jr. & Neuhaus, F.C. (1969). „The initial stage in peptidoglycan synthesis. IV. Solubilization of phospho-N-acetylmuramyl-pentapeptide translocase”. Biochemistry. 8: 1474—1481. PMID 5805290.
- ^ Higashi, Y., Strominger, J.L. and Sweeley, C.C. (1967). „Structure of a lipid intermediate in cell wall peptidoglycan synthesis: a derivative of a C55 isoprenoid alcohol”. Proc. Natl. Acad. Sci. USA. 57: 1878—1884. PMID 5231417.
- ^ Struve, W.G., Sinha, R.K. and Neuhaus, F.C. (1966). „On the initial stage in peptidoglycan synthesis. Phospho-N-acetylmuramyl-pentapeptide translocase (uridine monophosphate)”. Biochemistry. 5: 82—93. PMID 5938956.
- ^ van Heijenoort, J. (2001). „Recent advances in the formation of the bacterial peptidoglycan monomer unit”. Nat. Prod. Rep. 18: 503—519. PMID 11699883.
Literatura
uredi- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
uredi- Phospho-N-acetylmuramoyl-pentapeptide-transferase na US National Library of Medicine Medical Subject Headings (MeSH)
