Hinin 3-monooksigenaza
Hinin 3-monooksigenaza (EC 1.14.13.67, hininska 3-hidroksilaza) je enzim sa sistematskim imenom hinin,NADPH:kiseonik oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
Hinin 3-monooksigenaza | |||||||||
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Identifikatori | |||||||||
EC broj | 1.14.13.67 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- hinin + NADPH + H+ + O2 3-hidroksihinin + NADP+ + H2O
Reference
uredi- ^ Relling, M.V., Evans, R., Dass, C., Desiderio, D.M. and Nemec, J. (1992). „Human cytochrome P450 metabolism of teniposide and etoposide”. J. Pharmacol. Exp. Ther. 261: 491—496. PMID 1578365.
- ^ Zhang, H., Coville, P.F., Walker, R.J., Miners, J.O., Birkett, D.J. and Wanwimolruk, S. (1997). „Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine”. Br. J. Clin. Pharmacol. 43: 245—252. PMID 9088578.
- ^ Zhao, X.-J., Kawashiro, T. and Ishizaki, T. (1998). „Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways”. Drug Metab. Dispos. 26: 188—191. PMID 9456308.
- ^ Zhao, X.-J., Yokoyama, H., Chiba, K., Wanwimolruk, S. and Ishizaki, T. (1996). „Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human liver microsomes and nine recombinant human cytochromes P450”. J. Pharmacol. Exp. Ther. 279: 1327—1334. PMID 8968357.
Literatura
uredi- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
uredi- Quinine+3-monooxygenase na US National Library of Medicine Medical Subject Headings (MeSH)