Hromopirolatna sintaza
Hromopirolatna sintaza (EC 4.3.1.26, RebD, hromopirolinsko kiselinska sintaza) je enzim sa sistematskim imenom 2-imino-3-(7-hloroindol-3-il)propanoat amonijak-lijaza (formira dihlorohromopirolat).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Hromopirolatna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.3.1.26 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2 2-imino-3-(7-hloroindol-3-il)propanoat dihlorohromopirolat + NH3
Ovaj enzim učestvuje u biosintezi rebekamicina.
Reference uredi
- ^ Nishizawa, T., Gruschow, S., Jayamaha, D.H., Nishizawa-Harada, C. and Sherman, D.H. (2006). „Enzymatic assembly of the bis-indole core of rebeccamycin”. J. Am. Chem. Soc. 128: 724—725. PMID 16417354.
- ^ Howard-Jones, A.R. & Walsh, C.T. (2005). „Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD”. Biochemistry. 44: 15652—15663. PMID 16313168.
Literatura uredi
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze uredi
- Chromopyrrolate+synthase na US National Library of Medicine Medical Subject Headings (MeSH)
