Kalikrein plazme
Kalikrein plazme (EC 3.4.21.34, kininogenin, kalikrein I, kalikrein II, kininogenaza, kalikrein, kalikrein, glumorin, padreatin, padutin, kalidinogenaza, bradikininogenaza, pankeasni kalikrein, onokrein P, dilminal D, depot-Padutin, urokalikrein, urinarni kalikrein) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Kalikrein plazme | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.34 | ||||||||
| CAS broj | 410538-33-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Selectivno razlaganje pojedinih tipova Arg- i Lys- veza, uključujući Lys-Arg - Arg-Ser i (ljudskom) kininogenu čime se oslobađa bradikinin
Ovaj enzim se formira iz prokalikreina iz plazme dejstvom faktora XIIa.
Reference uredi
- ^ Heimark, R.L. & Davie, E.W. (1981). „Bovine and human plasma prekallikrein”. Methods Enzymol. 80: 157—172. PMID 6918767.
- ^ McRae, B.J., Kurachi, K., Heimark, R.L., Fujikawa, K., Davie, E.W. and Powers, J.C. (1981). „Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates”. Biochemistry. 20: 7196—7206. PMID 6976185.
- ^ Silverberg, M. & Kaplan, A.P. (1988). „Prekallikrein”. Methods Enzymol. 163: 85—95. PMID 3237096.
- ^ Seidah, N.G., Ladenheim, R., Mbikay, M., Hamelin, J., Lutfalla, G., Rougeon, F., Lazure, C. and Chrétien, M. (1989). „The cDNA structure of rat plasma kallikrein”. DNA. 8: 563—574. PMID 2598771.
- ^ Tsuda, Y., Teno, N., Okada, Y., Wanaka, K., Bohgaki, M., Hijikata-Okunomiya, A., Okamoto, U., Naito, T. and Okamoto, S. (1989). „Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein”. Chem. Pharm. Bull. 37: 3108—3111. PMID 2534361.
Literatura uredi
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze uredi
- Plasma+kallikrein na US National Library of Medicine Medical Subject Headings (MeSH)
