Malat dehidrogenaza (hinon)
Malat dehidrogenaza (hinon) (EC 1.1.5.4, FAD-zavisna malat-vitamin K reduktaza, malat-vitamin K reduktaza, (S)-malat:(akceptor) oksidoreduktaza, L-malat-hinonska oksidoreduktaza, malat:hinon oksidoreduktaza, malat hinonska oksidoreduktaza, MQO, malat:hinon reduktaza, malatna dehidrogenaza (akceptor), FAD-zavisna malatna dehidrogenaza) je enzim sa sistematskim imenom (S)-malat:hinon oksidoreduktaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Malat dehidrogenaza (hinon) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.5.4 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (S)-malat + hinon oksaloacetat + redukovani hinon
Ovaj enzim je flavoprotein (FAD). Vitamin K i nekoliko drugih hinona mogu da deluju kao akceptori. On se razlikuje od EC 1.1.1.37 (malat dehidrogenaze (NAD+)), EC 1.1.1.82 (malat dehidrogenaza (NADP+)) i EC 1.1.1.299 (malat dehidrogenaza (NAD(P)+)).
Reference
uredi- ^ Imai, D. & Brodie, A.F. (1973). „A phospholipid-requiring enzyme, malate-vitamin K reductase”. J. Biol. Chem. 248: 7487—7494.
- ^ Imai, T. (1978). „FAD-dependent malate dehydrogenase, a phospholipid-requiring enzyme from Mycobacterium sp. strain Takeo. Purification and some properties”. Biochim. Biophys. Acta. 523: 37—46. PMID 629992.
- ^ Reddy, T.L.P., Suryanarayana, P.M. and Venkitasubramanian, T.A. (1975). „Variations in the pathways of malate oxidation and phosphorylation in different species of Mycobacteria”. Biochim. Biophys. Acta. 376: 210—218. PMID 234747.
- ^ Molenaar, D., van der Rest, M.E. and Petrovic, S. (1998). „Biochemical and genetic characterization of the membrane-associated malate dehydrogenase (acceptor) from Corynebacterium glutamicum”. Eur. J. Biochem. 254: 395—403. PMID 9660197.
- ^ Kather, B., Stingl, K., van der Rest, M.E., Altendorf, K. and Molenaar, D. (2000). „Another unusual type of citric acid cycle enzyme in Helicobacter pylori: the malate:quinone oxidoreductase”. J. Bacteriol. 182: 3204—3209. PMID 10809701.
Literatura
uredi- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
uredi- Malate+dehydrogenase+(quinone) na US National Library of Medicine Medical Subject Headings (MeSH)
