Pantetein-fosfat adenililtransferaza
Pantetein-fosfat adenililtransferaza (EC 2.7.7.3, defosfo-KoA pirofosforilaza, pantetein fosfat adenililtransferaza, defosfo-koenzim A pirofosforilaza, 3'-defosfo-KoA pirofosforilaza) je enzim sa sistematskim imenom ATP:pantetein-4'-fosfat adenililtransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
Pantetein-fosfat adenililtransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.7.7.3 | ||||||||
CAS broj | 9026-99-7 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Enzim iz nekoliko bakterija (e.g. Escherichia coli, Bacillus subtilis i Haemophilus influenzae) je bifunkcionalan.
Reference
uredi- ^ Hoagland, M.B. & Novelli, G.D. (1954). „Biosynthesis of coenzyme A from phosphopantetheine and pantetheine from pantothenate”. J. Biol. Chem. 207: 767—773. PMID 13163064.
- ^ Novelli, G.D. (1953). „Enzymatic synthesis and structure of CoA”. Fed. Proc. 12: 675—682. PMID 13107738.
- ^ Martin, D.P. & Drueckhammer, D.G. (1993). „Separate enzymes catalyze the final two steps of coenzyme A biosynthesis in Brevibacterium ammoniagenes: purification of pantetheine phosphate adenylyltransferase”. Biochem. Biophys. Res. Commun. 192: 1155—1161. PMID 8389542.
- ^ Geerlof, A., Lewendon, A. and Shaw, W.V. (1999). „Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli”. J. Biol. Chem. 274: 27105—27111. PMID 10480925.
- ^ Izard, T., Geerlof, A., Lewendon, A. and Barker, J.J. (1999). „Cubic crystals of phosphopantetheine adenylyltransferase from Escherichiacoli”. Acta Crystallogr. D Biol. Crystallogr. 55: 1226—1228. PMID 10329792.
Literatura
uredi- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
uredi- Pantetheine-phosphate+adenylyltransferase na US National Library of Medicine Medical Subject Headings (MeSH)