Piruvat sintaza
Piruvat sintaza (EC 1.2.7.1, piruvatna oksidoreduktaza, piruvatna sintetaza, piruvat:feredoksin oksidoreduktaza, piruvinska-feredoksinska oksidoreduktaza) je enzim sa sistematskim imenom piruvat:feredoksin 2-oksidoreduktaza (KoA-acetilacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Piruvat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 1.2.7.1 | ||||||||
| CAS broj | 9082-51-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- piruvat + KoA + 2 oksidovani feredoksin acetil-KoA + CO2 + 2 redukovani feredoksin + 2 H+
Ovaj enzim sadrži tiamin difosfat i [4Fe-4S] klastere. On je jedan od četiri 2-oksokiselinske oksidoreduktaze koji se razlikujuj po njihovoj sposobnosti da oksidativno dekarboksiluju različite 2-oksokiseline i formiraju KoA derivate, cf. EC 1.2.7.3, 2-oksoglutarat sintaza, EC 1.2.7.7, 3-metil-2-oksobutanoat dehidrogenaza (feredoksin) i EC 1.2.7.8, indolpiruvat feredoksin oksidoreduktaza.
Reference
uredi- ^ Evans, M.C.W. & Buchanan, B.B. (1965). „Photoreduction of ferredoxin and its use in carbon dioxide fixation by a subcellular system from a photosynthetic bacterium”. Proc. Natl. Acad. Sci. USA. 53: 1420—1425. PMID 5217644.
- ^ Gehring, U. & Arnon, D.I. (1972). „Purification and properties of α-ketoglutarate synthase from a photosynthetic bacterium”. J. Biol. Chem. 247: 6963—6969. PMID 4628267.
- ^ Uyeda, K. & Rabinowitz, J.C. (1971). „Pyruvate-ferredoxin oxidoreductase. 3. Purification and properties of the enzyme”. J. Biol. Chem. 246: 3111—3119. PMID 5574389.
- ^ Uyeda, K. & Rabinowitz, J.C. (1971). „Pyruvate-ferredoxin oxidoreductase. IV. Studies on the reaction mechanism”. J. Biol. Chem. 246: 3120—3125. PMID 4324891.
- ^ Charon, M.-H., Volbeda, A., Chabriere, E., Pieulle, L. and Fontecilla-Camps, J.C. (1999). „Structure and electron transfer mechanism of pyruvate:ferredoxin oxidoreductase”. Curr. Opin. Struct. Biol. 9: 663—669. PMID 10607667.
Literatura
uredi- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
uredi- Pyruvate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
