TRNKIle-lizidinska sintaza
TRNKIle-lizidinska sintaza (EC 6.3.4.19, TilS, mesJ (gen), yacA (gen), izoleucin-specifični transfer ribonukleat lizidinska sintetaza, tRNKIle-lizidinska sintetaza) je enzim sa sistematskim imenom L-lizin:(tRNKIle2)-citidin34 ligaza (formira AMP).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| TRNKIle-lizidinska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.4.19 | ||||||||
| CAS broj | 635304-92-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Bakterijski enzim modifikuje nestabilnu bazu CAU antikodona u tRNKIle molekulu.
Reference
uredi- ^ Ikeuchi, Y., Soma, A., Ote, T., Kato, J., Sekine, Y. and Suzuki, T. (2005). „molecular mechanism of lysidine synthesis that determines tRNA identity and codon recognition”. Mol. Cell. 19: 235—246. PMID 16039592.
- ^ Salowe, S.P., Wiltsie, J., Hawkins, J.C. and Sonatore, L.M. (2009). „The catalytic flexibility of tRNAIle-lysidine synthetase can generate alternative tRNA substrates for isoleucyl-tRNA synthetase”. J. Biol. Chem. 284: 9656—9662. PMID 19233850.
- ^ Nakanishi, K., Fukai, S., Ikeuchi, Y., Soma, A., Sekine, Y., Suzuki, T. and Nureki, O. (2005). „Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain”. Proc. Natl. Acad. Sci. USA. 102: 7487—7492. PMID 15894617.
- ^ Soma, A., Ikeuchi, Y., Kanemasa, S., Kobayashi, K., Ogasawara, N., Ote, T., Kato, J., Watanabe, K., Sekine, Y. and Suzuki, T. (2003). „An RNA-modifying enzyme that governs both the codon and amino acid specificities of isoleucine tRNA”. Mol. Cell. 12: 689—698. PMID 14527414.
- ^ Nakanishi, K., Bonnefond, L., Kimura, S., Suzuki, T., Ishitani, R. and Nureki, O. (2009). „Structural basis for translational fidelity ensured by transfer RNA lysidine synthetase”. Nature. 461: 1144—1148. PMID 19847269.
Literatura
uredi- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
uredi- TRNAIle-lysidine+synthase na US National Library of Medicine Medical Subject Headings (MeSH)
