Tetrahidroksinaftalen reduktaza
Tetrahidroksinaftalen reduktaza (EC 1.1.1.252, tetrahidroksinaftalenska reduktaza) je enzim sa sistematskim imenom scitalon:NADP+ Delta5-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Tetrahidroksinaftalen reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.252 | ||||||||
| CAS broj | 141350-13-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- scitalon + NADP+ 1,3,6,8-tetrahidroksinaftalen + NADPH + H+
Tetrahidroksinaftalenska reduktaza redukuje 1,3,6,8-tetrahidroksinaftalen do scitalona i takođe redukuje 1,3,8-trihidroksinaftalen do vermelona. Ona učestvuje sa EC 4.2.1.94, scitalonskom dehidratazom, u biosintezi melanina kod patogenih gljiva.
Reference
uredi- ^ Wheeler, M.H. & Greenblatt, G.A. (1988). „The inhibition of melanin biosynthetic reactions in Pyricularia oryzae' by compounds that prevent rice blast disease”. Exp. Mycol. 12: 151—160.
- ^ Vidal-Cros, A., Viviani, F., Labesse, G., Boccara, M. and Gaudry, M. (1994). „Polyhydroxynaphthalene reductase involved in melanin biosynthesis in Magnaporthe grisea. Purification, cDNA cloning and sequencing”. Eur. J. Biochem. 219: 985—992. PMID 8112349.
- ^ Thompson, J.E., Basarab, G.S., Andersson, A., Lindqvist, Y. and Jordan, D.B. (1997). „Trihydroxynaphthalene reductase from Magnaporthe grisea: realization of an active center inhibitor and elucidation of the kinetic mechanism”. Biochemistry. 36: 1852—1860. PMID 9048570.
Literatura
uredi- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
uredi- Tetrahydroxynaphthalene+reductase na US National Library of Medicine Medical Subject Headings (MeSH)
