2'-N-acetilparomaminska deacetilaza
2'-N-acetilparomaminska deacetilaza (EC 3.5.1.112, btrD (gen), neoL (gen), kanN (gen)) je enzim sa sistematskim imenom 2'-N-acetilparomamin hidrolaza (formira acetat).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
2'-N-acetilparomaminska deacetilaza | |||||||||
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Identifikatori | |||||||||
EC broj | 3.5.1.112 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ovaj enzim učestvuje u biosintezi nekoliko klinički važnih aminociklitolnih antibiotika.
Reference
уреди- ^ Truman, A.W., Huang, F., Llewellyn, N.M. and Spencer, J.B. (2007). „Characterization of the enzyme BtrD from Bacillus circulans and revision of its functional assignment in the biosynthesis of butirosin”. Angew. Chem. Int. Ed. Engl. 46: 1462—1464. PMID 17226887.
- ^ Yokoyama, K., Yamamoto, Y., Kudo, F. and Eguchi, T. (2008). „Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis”. ChemBioChem. 9: 865—869. PMID 18311744.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- 2'-N-acetylparomamine+deacetylase на US National Library of Medicine Medical Subject Headings (MeSH)