Adenozilkobinamid-GDP ribazoltransferaza
Adenozilkobinamid-GDP ribazoltransferaza (EC 2.7.8.26, CobS, kobalaminska sintaza, kobalamin-5'-fosfat sintaza, kobalamin (5'-fosfat) sintaza) je enzim sa sistematskim imenom adenozilkobinamid-GDP:alfa-ribazol ribazoltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Adenozilkobinamid-GDP ribazoltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.8.26 | ||||||||
| CAS broj | 137672-85-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- (1) adenozilkobinamid-GDP + alfa-ribazol GMP + adenozilkobalamin
- (2) adenozilkobinamid-GDP + alfa-ribazol 5'-fosfat GMP + adenozilkobalamin 5'-fosfat
Kod Salmonella typhimurium LT2, pri anaerobnim uslovima, CobU (EC 2.7.7.62 i EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) i CobS (EC 2.7.8.26) katalizuje reakcije biosinteze nukleotidne petlje, kojima se konvertuje adenozilkobinamid (AdoCbi) u adenozilkobalamin (AdoCbl).
Reference
уреди- ^ Maggio-Hall, L.A. & Escalante-Semerena, J.C. (1999). „In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes”. Proc. Natl. Acad. Sci. USA. 96: 11798—11803. PMID 10518530.
- ^ Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C. (2002). „The biosynthesis of adenosylcobalamin (vitamin B12)”. Nat. Prod. Rep. 19: 390—412. PMID 12195810.
- ^ Cameron, B., Blanche, F., Rouyez, M.C., Bisch, D., Famechon, A., Couder, M., Cauchois, L., Thibaut, D., Debussche, L. and Crouzet, J. (1991). „Genetic analysis, nucleotide sequence, and products of two Pseudomonas denitrificans cob genes encoding nicotinate-nucleotide: dimethylbenzimidazole phosphoribosyltransferase and cobalamin (5′-phosphate) synthase”. J. Bacteriol. 173: 6066—6073. PMID 1917841.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Adenosylcobinamide-GDP+ribazoletransferase на US National Library of Medicine Medical Subject Headings (MeSH)
