Atiprosin
Atiprosin (AY-28,228) je antihipertenzivni lek koji se koristi kao selektivni antagonist α1-adrenergičkog receptora.[1][2][3][4] On takođe poseduje izvesnu antihistaminsku aktivnost, mada je ona slaba.[3] On nije plasiran na tržište.[1]
IUPAC ime | |
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(4aR,12bS)-1-etil-12-metil-4-(propan-2-il)-1,2,3,4,4a,5,6,12b-oktahidropirazino[2',3':3,4]pirido[1,2-a]indol | |
Klinički podaci | |
Način primene | Oralno |
Pravni status | |
Pravni status |
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Identifikatori | |
CAS broj | 89303-63-9 [] |
ATC kod | none |
PubChem | CID 71770 |
ChemSpider | 64808 |
UNII | ALS52889WF |
Hemijski podaci | |
Formula | C20H29N3 |
Molarna masa | 311,46 g/mol |
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Sinteza
уредиJedan od mogućih sintetičkih puteva je[5]:
Reference
уреди- ^ а б Triggle, David J. (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 978-0-412-46630-4.
- ^ Jirkovsky I, Santroch G, Baudy R, Oshiro G (1987). „Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents”. Journal of Medicinal Chemistry. 30 (2): 388—94. PMID 3806618. doi:10.1021/jm00385a022.
- ^ а б Grimes D; Rimele TJ; Henry DE; et al. (1987). „In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound”. Journal of Cardiovascular Pharmacology. 10 (3): 249—58. PMID 2444771. doi:10.1097/00005344-198709000-00001.
- ^ Oshiro G, Wojdan A, Klein M, Metcalf G (1987). „Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys”. Journal of Cardiovascular Pharmacology. 10 (3): 341—9. PMID 2444784. doi:10.1097/00005344-198709000-00014.
- ^ Jirkovsky, Ivo; George Santroch; Reinhardt Baudy; George Oshiro (1987). „Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents”. Journal of Medical Chemistry. 30 (2): 388—394. PMID 3806618. doi:10.1021/jm00385a022.