Citikolin

Citikolin
IUPAC ime
	5'-O-[hidroksi({hidroksi[2-(trimetilamonio)etoksi]; fosforil}oksi)fosforil]citidin
Klinički podaci
Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	987-78-0
ATC kod	N06BX06 (WHO)
PubChem	CID 13805
ChemSpider	16736209
UNII	536BQ2JVC7
KEGG	D00057
ChEMBL	CHEMBL1618340
Sinonimi	Cytidine diphosphate choline
Hemijski podaci
Formula	C14H27N4O11P2+
Molarna masa	489,332 g/mol
	SMILES C[N+](C)(C)OP([O-])(=O)OP(O)(=O)OC[C@H]2O[C@@H](N1/C=C\C(\N)=N/C1=O)[C@H](O)[C@@H]2O; ;
	InChI InChI=1S/C12H22N4O11P2/c1-16(2,3)26-29(22,23)27-28(20,21)24-6-7-9(17)10(18)11(25-7)15-5-4-8(13)14-12(15)19/h4-5,7,9-11,17-18H,6H2,1-3H3,(H3-,13,14,19,20,21,22,23)/t7-,9-,10-,11-/m1/s1 ; Key:OPDHNBAEGPICKZ-QCNRFFRDSA-N ;

Citikolin (citidin difosfat-holin, CDP-holin, citidin 5'-difosfoholin) je psihostimulans/nutropik. On je intermedijar u generaciji fosfatidilholina iz holina.

Ispitivanja sugerišu da CDP-holin suplementi povećavaju gustine dopaminskog receptora,^[1] i da pomažu u sprečavanju gubljenja memorije uzrokovanog lošim uslovima životne sredine.^[2] Preliminarna ispitivanja su utvrdila da citikolinski suplementi pomažu u poboljšanju fokusa i mentalne energije, te da potencijalno mogu da budu korisni u tretmanu deficita koncentracije.^[3]^[4] Citikolin isto tako povišava nivo ACTH-a nezavisno od nivoa CRH.^[5]

Reference уреди

^ Giménez R, Raïch J, Aguilar J (1991). „Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice”. British Journal of Pharmacology. 104 (3): 575—8. PMC 1908237  . PMID 1839138.
^ Teather LA, Wurtman RJ (2005). „Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats”. Learning & Memory. 12 (1): 39—43. PMC 548494  . PMID 15647594. doi:10.1101/lm.83905.
^ „Supplement naturally boosts ageing brain power”. Sydney Morning Herald. 25. 02. 2008. Приступљено 28. 07. 2009.
^ Silveri MM; Dikan J; Ross AJ; et al. (2008). „Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy”. NMR in Biomedicine. 21 (10): 1066—75. PMID 18816480. doi:10.1002/nbm.1281.
^ Cavun S, Savci V (2004). „CDP-choline increases plasma ACTH and potentiates the stimulated release of GH, TSH and LH: the cholinergic involvement”. Fundamental & Clinical Pharmacology. 18 (5): 513—23. PMID 15482372. doi:10.1111/j.1472-8206.2004.00272.x.

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[1] Giménez R, Raïch J, Aguilar J (1991). „Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice”. British Journal of Pharmacology. 104 (3): 575—8. PMC 1908237  . PMID 1839138.

[2] Teather LA, Wurtman RJ (2005). „Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats”. Learning & Memory. 12 (1): 39—43. PMC 548494  . PMID 15647594. doi:10.1101/lm.83905.

[3] „Supplement naturally boosts ageing brain power”. Sydney Morning Herald. 25. 02. 2008. Приступљено 28. 07. 2009.

[4] Silveri MM; Dikan J; Ross AJ; et al. (2008). „Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy”. NMR in Biomedicine. 21 (10): 1066—75. PMID 18816480. doi:10.1002/nbm.1281.

[5] Cavun S, Savci V (2004). „CDP-choline increases plasma ACTH and potentiates the stimulated release of GH, TSH and LH: the cholinergic involvement”. Fundamental & Clinical Pharmacology. 18 (5): 513—23. PMID 15482372. doi:10.1111/j.1472-8206.2004.00272.x.

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