D-alanin—D-serin ligaza
D-alanin—D-serin ligaza (EC 6.3.2.35, VanC, VanE, VanG) je enzim sa sistematskim imenom D-alanin:D-serin ligaza (formira ADP).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
D-alanin—D-serin ligaza | |||||||||
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Identifikatori | |||||||||
EC broj | 6.3.2.35 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Produkt ovog enzima, D-alanil-D-serin, može da bude inkorporiran u peptidoglikanski pentapeptid umesto uobičajenog D-alanil-D-alanin dipeptida.
Reference
уреди- ^ Dutka-Malen, S., Molinas, C., Arthur, M. and Courvalin, P. (1992). „Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a D-alanine:D-alanine ligase-related protein necessary for vancomycin resistance”. Gene. 112: 53—58. PMID 1551598.
- ^ Park, I.S., Lin, C.H. and Walsh, C.T. (1997). „Bacterial resistance to vancomycin: overproduction, purification, and characterization of VanC2 from Enterococcus casseliflavus as a D-Ala-D-Ser ligase”. Proc. Natl. Acad. Sci. USA. 94: 10040—10044. PMID 9294159.
- ^ Fines, M., Perichon, B., Reynolds, P., Sahm, D.F. and Courvalin, P. (1999). „VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis BM4405”. Antimicrob. Agents Chemother. 43: 2161—2164. PMID 10471558.
- ^ Depardieu, F., Bonora, M.G., Reynolds, P.E. and Courvalin, P. (2003). „The vanG glycopeptide resistance operon from Enterococcus faecalis revisited”. Mol. Microbiol. 50: 931—948. PMID 14617152.
- ^ Watanabe, S., Kobayashi, N., Quinones, D., Hayakawa, S., Nagashima, S., Uehara, N. and Watanabe, N. (2009). „Genetic diversity of the low-level vancomycin resistance gene vanC-2/vanC-3 and identification of a novel vanC subtype (vanC-4) in Enterococcus casseliflavus”. Microb. Drug Resist. 15: 1—9. PMID 19216682.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- D-alanine---D-serine+ligase на US National Library of Medicine Medical Subject Headings (MeSH)