Dimemorfan
Dimemorfan je antitusivni lek (supresant kašlja) koji deluje kao agonist sigma receptor.[1][2] On je analog dekstrometorfana i dekstrorfana, ali deluje kao antagonist NMDA receptora i nema disocijativne efekte, čime je umanjen njegov potencijal za zloupotrebu, kao i nuspojave.[3]
IUPAC ime | |
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(9α,13α,14α)-3,17-dimethylmorphinan | |
Identifikatori | |
CAS broj | 36309-01-0 |
ATC kod | R05DA11 (WHO) |
PubChem | CID 3037918 |
ChemSpider | 16735785 |
KEGG | D07848 |
Hemijski podaci | |
Formula | C18H25N |
Molarna masa | 255.398 g/mol |
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Vidi još
уредиReference
уреди- ^ Hui-Hung Wang, Jyh-Wei Chien, Yueh-Ching Chou, Jyh-Fei Liao and Chieh-Fu Chen. Anti-amnesic effect of dimemorfan in mice. British Journal of Pharmacology (2003) 138, 941–949.
- ^ Eun-Joo Shin, Seung-Yeol Nah, Won-Ki Kim, Kwang Ho Ko, Wang-Kee Jhoo, Yong-Kwang Lim, Joo Young Cha, Chieh-Fu Chen and Hyoung-Chun Kim. The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan. British Journal of Pharmacology (2005) 144, 908–918.
- ^ Chou YC, Liao JF, Chang WY, Lin MF, Chen CF (1999). „Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan”. Brain Research. 821 (2): 516—9. PMID 10064839. doi:10.1016/S0006-8993(99)01125-7.
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