Dualno specifična kinaza
Dualno specifična kinaza (EC 2.7.12.1, ADK1, Arabidopsis dualno specifična kinaza 1, CLK1, dDYRK2, Mps1p) je enzim sa sistematskim imenom ATP:protein fosfotransferaza (Ser/Thr- and Tyr-fosforilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Dualno specifična kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.12.1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ATP + protein ADP + fosfoprotein
Ova familija enzima može da fosforiliše Ser/Thr i Tyr ostatke.
Reference
уреди- ^ Ali, N., Halfter, U. and Chua, N.H. (1994). „Cloning and biochemical characterization of a plant protein kinase that phosphorylates serine, threonine, and tyrosine”. J. Biol. Chem. 269: 31626—31629. PMID 7527390.
- ^ Lauze, E., Stoelcker, B., Luca, F.C., Weiss, E., Schutz, A.R. and Winey, M. (1995). „Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase”. EMBO J. 14: 1655—1663. PMID 7737118.
- ^ Menegay, H.J., Myers, M.P., Moeslein, F.M. and Landreth, G.E. (2000). „Biochemical characterization and localization of the dual specificity kinase CLK1”. J. Cell Sci. 113: 3241—3253. PMID 10954422.
- ^ Lochhead, P.A., Sibbet, G., Kinstrie, R., Cleghon, T., Rylatt, M., Morrison, D.K. and Cleghon, V. (2003). „dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila”. Biochem. J. 374: 381—391. PMID 12786602.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Dual-specificity+kinase на US National Library of Medicine Medical Subject Headings (MeSH)
