Fosfolipid-translocirajuća ATPaza
Fosfolipid-translocirajuća ATPaza (EC 3.6.3.1, Mg2+-ATPaza, flipaza, aminofosfolipid-transportna ATPaza) je enzim sa sistematskim imenom ATP fosfohidrolaza (translokacija fosfolipida).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fosfolipid-translocirajuća ATPaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.3.1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ATP + H2O + fosfolipid [strana 1] ADP + fosfat + fosfolipid [strana 2]
Ova P-tip ATPaza podleže kovalentnoj fosforilaciji tokom transportnog ciklusa.
Reference
уреди- ^ Morris, M.B., Auland, M.E., Xu, Y.H. and Roufogalis, B.D. (1993). „Characterization of the Mg2+-ATPase activity of the human erythrocyte membrane”. Biochem. Mol. Biol. Int. 31: 823—832. PMID 8136700.
- ^ Vermeulen, W.P., Briede, J.J. and Rolofsen, B. (1996). „Manipulation of the phosphatidylethanolamine pool in the human red cell membrane affects its Mg2+-ATPase activity”. Mol. Membr. Biol. 13: 95—102. PMID 8839453.
- ^ Suzuki, H., Kamakura, M., Morii, M. and Takeguchi, N. (1997). „The phospholipid flippase activity of gastric vesicles”. J. Biol. Chem. 272: 10429—10434. PMID 9099684.
- ^ Auland, M.E., Roufogalis, B.D., Devaux, P.F. and Zachowski, A. (1994). „Reconstitution of ATP-dependent aminophospholipid translocation in proteoliposomes”. Proc. Natl. Acad. Sci. USA. 91: 10938—10942. PMID 7971987.
- ^ Alder-Baerens, N., Lisman, Q., Luong, L., Pomorski, T. and Holthuis, J.C. (2006). „Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles”. Mol. Biol. Cell. 17: 1632—1642. PMID 16452632.
- ^ Lopez-Marques, R.L., Poulsen, L.R., Hanisch, S., Meffert, K., Buch-Pedersen, M.J., Jakobsen, M.K., Pomorski, T.G. and Palmgren, M.G. (2010). „Intracellular targeting signals and lipid specificity determinants of the ALA/ALIS P4-ATPase complex reside in the catalytic ALA α-subunit”. Mol. Biol. Cell. 21: 791—801. PMID 20053675.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Phospholipid-translocating+ATPase на US National Library of Medicine Medical Subject Headings (MeSH)
