Homoakonitatna hidrataza
Homoakonitatna hidrataza (EC 4.2.1.36, homoakonitaza, cis-homoakonitaza, HACN, Lys4, LysF, 2-hidroksibutan-1,2,4-trikarboksilat hidrolijaza) je enzim sa sistematskim imenom (1R,2S)-1-hidroksibutan-1,2,4-trikarboksilat hidrolijaza (formira (Z)-but-1-en-1,2,4-trikarboksilat).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Homoakonitatna hidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.36 | ||||||||
| CAS broj | 9030-68-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1R,2S)-1-hidroksibutan-1,2,4-trikarboksilat (Z)-but-1-en-1,2,4-trikarboksilat + H2O
Za dejstvo ovog enzima je neophodan [4Fe-4S] klaster.
Reference
уреди- ^ Strassman, M. & Ceci, L.N. (1966). „Enzymatic formation of cis-homoaconitic acid, an intermediate in lysine biosynthesis in yeast”. J. Biol. Chem. 241: 5401—5407. PMID 5954805.
- ^ Jia, Y., Tomita, T., Yamauchi, K., Nishiyama, M. and Palmer, D.R. (2006). „Kinetics and product analysis of the reaction catalysed by recombinant homoaconitase from Thermus thermophilus”. Biochem. J. 396: 479—485. PMID 16524361.
- ^ Zabriskie, T.M. & Jackson, M.D. (2000). „Lysine biosynthesis and metabolism in fungi”. Nat. Prod. Rep. 17: 85—97. PMID 10714900.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Homoaconitate+hydratase на US National Library of Medicine Medical Subject Headings (MeSH)
