Karoksazon
Karoksazon (Surodil, Timostenil) je antidepresiv koji se nekad koristio za tretman depresije ali više nije u prodaji.[1][2] On deluje kao reverzibilni inhibitor monoaminske oksidaze (MAOI) oba podtipa: MAO-A i MAO-B, sa pet puta većom potentnošću na MAO-B.[3][4][5][6][7]
IUPAC ime | |
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2-(2-okso-4H-1,3-benzoksazin-3-il)acetamid | |
Klinički podaci | |
Kategorija trudnoće |
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Način primene | Oralno |
Pravni status | |
Pravni status |
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Identifikatori | |
CAS broj | 18464-39-6 |
ATC kod | none |
PubChem | CID 29083 |
ChemSpider | 27057 |
UNII | 807N226MNL |
Hemijski podaci | |
Formula | C10H10N2O3 |
Molarna masa | 206,20 g/mol |
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Reference
уреди- ^ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
- ^ Cecchini S, Petri P, Ardito R, Bareggi SR, Torriti A (1978). „A comparative double-blind trial of the new antidepressant caroxazone and amitriptyline”. The Journal of International Medical Research. 6 (5): 388—94. PMID 359383.
- ^ Lieberman, A. N. (1994). Monoamine oxidase inhibitors in neurological diseases. New York: M. Dekker. ISBN 0-8247-9082-0.
- ^ Moretti A; Caccia C; Martini A; et al. (1981). „Effect of caroxazone, a new antidepressant drug, on monoamine oxidases in healthy volunteers”. British Journal of Clinical Pharmacology. 11 (5): 511—5. PMC 1401585 . PMID 7272163.
- ^ Moretti A, Caccia C, Calderini G, Menozzi M, Amico A (1981). „Studies on the mechanism of action of caroxazone, a new antidepressant drug”. Biochemical Pharmacology. 30 (19): 2728—31. PMID 6170295. doi:10.1016/0006-2952(81)90549-9.
- ^ Martini A, Bonollo L, Nicolis FB, Sega R, Palermo A (1981). „Effects of caroxazone, a reversible monoamine oxidase inhibitor, on the pressor response to oral tyramine in man”. British Journal of Clinical Pharmacology. 11 (6): 611—5. PMC 1402186 . PMID 7272178.
- ^ Martini A, Bonollo L, Nicolis FB, Sega R, Palermo A, Braibanti E (1981). „Effects of caroxazone, a reversible monoamine oxidase inhibitor, on the pressor response to intravenous tyramine in man”. British Journal of Clinical Pharmacology. 11 (6): 605—10. PMC 1402193 . PMID 7272177.
Literatura
уреди- Lieberman, A. N. (1994). Monoamine oxidase inhibitors in neurological diseases. New York: M. Dekker. ISBN 0-8247-9082-0.
- Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.