Klotiazepam je organsko jedinjenje, koje sadrži 16 atoma ugljenika i ima molekulsku masu od 318,821 Da.[1][2][3]

Klotiazepam
Klinički podaci
Prodajno imeClozan, Distensan, Rize, Rizen
Drugs.comMonografija
Način primeneOralno
Farmakokinetički podaci
Poluvreme eliminacije4 h
Identifikatori
CAS broj33671-46-4 ДаY
ATC kodNone
PubChemCID 2811
DrugBankDB01559 ДаY
ChemSpider2709 ДаY
Hemijski podaci
FormulaC16H15ClN2OS
Molarna masa318,821
  • CCC1=CC2=C(S1)N(C)C(=O)CN=C2C1=CC=CC=C1Cl
  • InChI=1S/C16H15ClN2OS/c1-3-10-8-12-15(11-6-4-5-7-13(11)17)18-9-14(20)19(2)16(12)21-10/h4-8H,3,9H2,1-2H3 ДаY
  • Key:CHBRHODLKOZEPZ-UHFFFAOYSA-N ДаY
Fizički podaci
Tačka topljenja118—120 °C (244—248 °F)
Osobina Vrednost
Broj akceptora vodonika 2
Broj donora vodonika 0
Broj rotacionih veza 2
Particioni koeficijent[4] (ALogP) 3,8
Rastvorljivost[5] (logS, log(mol/L)) -5,6
Polarna površina[6] (PSA, Å2) 60,9

Reference

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  1. ^ Nakazawa Y, Kotorii M, Oshima M, Horikawa S, Tachibana H: Effects of thienodiazepine derivatives on human sleep as compared to those of benzodiazepine derivatives. Psychopharmacologia. 1975 Oct 31;44(2):165-71. PMID 709
  2. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.  уреди
  3. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.  уреди
  4. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  5. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.  уреди
  6. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.  уреди

Literatura

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Spoljašnje veze

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