Metilmalonat-semialdehid dehidrogenaza (acilacija)
Metilmalonat-semialdehid dehidrogenaza (acilacija) (EC 1.2.1.27, MSDH, MMSA dehidrogenaza) je enzim sa sistematskim imenom 2-metil-3-oksopropanoat:NAD+ 3-oksidoreduktaza (KoA-propanoilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
Metilmalonat-semialdehid dehidrogenaza (acilacija) | |||||||||
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Identifikatori | |||||||||
EC broj | 1.2.1.27 | ||||||||
CAS broj | 37205-49-5 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 2-metil-3-oksopropanoat + KoA +H2O + NAD+ propanoil-KoA + HCO3- + NADH
Ovaj enzim takođe konvertuje 3-oksopropanoat u acetil-KoA. Reakcija se odvija u dva koraka, pri čemu dekarboksilacioni process teče uz KoA vezivanje. Bikarbonat umesto CO2 se oslobađa kao finalni produkt.
Reference
уреди- ^ Sokatch, J.R., Sanders, L.E. and Marshall, V.P. (1968). „Oxidation of methylmalonate semialdehyde to propionyl coenzyme A in Pseudomonas aeruginosa grown on valine”. J. Biol. Chem. 243: 2500—2506. PMID 4297649.
- ^ Dubourg, H., Stines-Chaumeil, C., Didierjean, C., Talfournier, F., Rahuel-Clermont, S., Branlant, G. and Aubry, A. (2004). „Expression, purification, crystallization and preliminary X-ray diffraction data of methylmalonate-semialdehyde dehydrogenase from Bacillus subtilis”. Acta Crystallogr. D Biol. Crystallogr. 60: 1435—1437. PMID 15272169.
- ^ Stines-Chaumeil, C., Talfournier, F. and Branlant, G. (2006). „Mechanistic characterization of the MSDH (methylmalonate semialdehyde dehydrogenase) from Bacillus subtilis”. Biochem. J. 395: 107—115. PMID 16332250.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Methylmalonate-semialdehyde+dehydrogenase+(acylating) на US National Library of Medicine Medical Subject Headings (MeSH)