Pirolizin—tRNKPil ligaza
Pirolizin—tRNKPil ligaza (EC 6.1.1.26, PylS, pirolizil-tRNK sintetaza) je enzim sa sistematskim imenom L-pirrolizin:tRNKPil ligaza (formira AMP).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Pirolizin—tRNKPil ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.1.1.26 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
U organizmima kao što je metanosarcina barkeri koji inkorporiraju modifikovanu aminokiselinu pirolizin (Pyl) u pojedine metilaminske metiltransferaze, jedana neobična tRNKPyl, sa CUA antikodonom, može direktno da veže pirolizin posredstvom ove klase II aminoacil-tRNK ligaza.
Reference
уреди- ^ Blight, S.K., Larue, R.C., Mahapatra, A., Longstaff, D.G., Chang, E., Zhao, G., Kang, P.T., Green-Church, K.B., Chan, M.K. and Krzycki, J.A. (2004). „Direct charging of tRNA(CUA) with pyrrolysine in vitro and in vivo”. Nature. 431: 333—335. PMID 15329732.
- ^ Polycarpo, C., Ambrogelly, A., Bérubé, A., Winbush, S.M., McCloskey, J.A., Crain, P.F., Wood, J.L. and Söll, D. (2004). „An aminoacyl-tRNA synthetase that specifically activates pyrrolysine”. Proc. Natl. Acad. Sci. USA. 101: 12450—12454. PMID 15314242.
- ^ Schimmel, P. & Beebe, K. (2004). „Molecular biology: genetic code seizes pyrrolysine”. Nature. 431: 257—258. PMID 15372017.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Pyrrolysine---tRNAPyl+ligase на US National Library of Medicine Medical Subject Headings (MeSH)
