TRNK nukleotidiltransferaza
TRNK nukleotidiltransferaza (EC 2.7.7.56, fosfat-zavisna eksonukleaza, RNaza PH, ribonukleaza PH) je enzim sa sistematskim imenom tRNK:fosfat nukleotidiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| TRNK nukleotidiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 RNaza PH hexamer, Pseudomonas aeruginosa | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.7.7.56 | ||||||||
| CAS broj | 116412-36-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- tRNKn+1 + fosfat tRNKn + nukleozid difosfat
Ovaj enzim vrši finalno eksonukleolitičko odsecanje na 3'-terminusu tRNK prekurzora kod Escherichia coli putem fosforolize.
Reference
уреди- ^ Cudny, H. & Deutscher, M.P. (1988). „3′ processing of tRNA precursors in ribonuclease-deficient Escherichia coli. Development and characterization of an in vitro processing system and evidence for a phosphate requirement”. J. Biol. Chem. 263: 1518—1523. PMID 3275667.
- ^ Deutscher, M.P., Marshall, G.T. and Cudny, H. (1988). „RNase PH: an Escherichia coli phosphate-dependent nuclease distinct from polynucleotide phosphorylase”. Proc. Natl. Acad. Sci. USA. 85: 4710—4714. PMID 2455297.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- TRNA+nucleotidyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
