Alifatična nitrilaza
Alifatična nitrilaza (EC 3.5.5.7) je enzim sa sistematskim imenom alifatični nitril aminohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Alifatična nitrilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.5.7 | ||||||||
| CAS broj | 395644-15-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- R-CN + 2 H 2O R-COOH + NH3
Ovaj enzim preferentno hidrolizuje alifatične nitrile.
Reference уреди
- ^ Kobayashi, M., Yanaka, N., Nagasawa, T., Yamada, H. (1992). „Primary structure of an aliphatic nitrile-degrading enzyme, aliphatic nitrilase from Rhodococcus rhodochrous K22 and expression of its gene and identification of its active site residue”. Biochemistry. 31: 9000—9007. PMID 1390687.
- ^ Pace, H.C. & Brenner, C. (2001). „The nitrilase superfamily: classification, structure and function”. Genome Biol. 2: 0001.—001.9. PMID 11380987.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Aliphatic+nitrilase на US National Library of Medicine Medical Subject Headings (MeSH)
