Desosaminil transferaza EryCIII
Desosaminil transferaza EryCIII (EC 2.4.1.278, EryCIII) je enzim sa sistematskim imenom dTDP-3-dimetilamino-4,6-didezoksi-alfa-D-glukopiranoza:3-alfa-mikarosileritronolid B 3-dimetilamino-4,6-didezoksi-alfa-D-glukoziltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Desosaminil transferaza EryCIII | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.278 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- dTDP-3-dimetilamino-4,6-didezoksi-alfa-D-glukopiranoza + 3-alfa-mikarosileritronolide B dTDP + eritromicin D
Ovaj enzim učestvuje u biosintezi eritromicina.
Reference уреди
- ^ Yuan, Y., Chung, H.S., Leimkuhler, C., Walsh, C.T., Kahne, D. and Walker, S. (2005). „In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides”. J. Am. Chem. Soc. 127: 14128—14129. PMID 16218575.
- ^ Lee, H.Y., Chung, H.S., Hang, C., Khosla, C., Walsh, C.T., Kahne, D. and Walker, S. (2004). „Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway”. J. Am. Chem. Soc. 126: 9924—9925. PMID 15303858.
- ^ Moncrieffe, M.C., Fernandez, M.J., Spiteller, D., Matsumura, H., Gay, N.J., Luisi, B.F. and Leadlay, P.F. (2012). „Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII”. J. Mol. Biol. 415: 92—101. PMID 22056329.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Desosaminyl+transferase+EryCIII на US National Library of Medicine Medical Subject Headings (MeSH)
