Dimetilglicin

Dimetilglicin
Nazivi
	IUPAC naziv 2-(Dimetilamino)sirćetna kiselina
	Drugi nazivi N,N-Dimetilglicin
Identifikacija
CAS broj	1118-68-9 ;
3D model (Jmol)	interaktivna slika; interaktivna slika;
3DMet	B00224
Bajlštajn	1700261
ChEBI	CHEBI:17724 ;
ChemSpider	653 ;
DrugBank	DB02083 ;
ECHA InfoCard	100.012.971
EC broj	214-267-8
Gmelin Referenca	82215
KEGG	C01026 ;
MeSH	dimethylglycine
PubChem C ID	673;
RTECS	MB9865000
	SMILES CN(C)Cc(:[o]):[oH]; CN(C)CC(O)=O; ; ; ; ;
Svojstva
Hemijska formula	C4H9NO2
Molarna masa	103,12 g·mol−1
Agregatno stanje	Beli kristali
Miris	Bez mirisa
Opasnosti
GHS grafikoni
GHS signalna reč	Oposnost
GHS opis opasnosti	H302
	Letalna doza ili koncentracija (LD, LC):
LD50 (LD50)	>650 mg kg−1 (oralno, pacov)
Srodna jedinjenja
Srodne alkanoinske kiseline	Sarkozin; Glikociamin; Kreatin; N-Metil-D-aspartinska kiselina; beta-Metilamino-L-alanin; Guanidinopropionska kiselina;
Srodna jedinjenja	Dimetilacetamid
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

Dimetilglicin (DMG) je derivat aminokiseline glicina sa strukturnom formulom (CH₃)₂NCH₂COOH. On je prisutan u pasulju i jetri. On se može formirati iz trimetilglicina nakon gubitka jedne od njegovih metil grupa. On je takođe nusproizvod metabolizma holina.

Upotrebe уреди

Dimetilglicin je predložen za moguću primenu kao sredstvo za poboljšanje atletske performance, imunostimulant, i za tretman autizma, epilepsije, i mitohondrijalne bolesti.^[5]^[6] Objavljene studije su pokazale da nema znatne razlike imeđu tretmana autiyma DMG-om i placebom.^[7]^[8]

Reference уреди

^ „dimethylglycine - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 16. 9. 2004. Identification. Приступљено 24. 4. 2012.
^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ „Dimethylglycine”. About Herbs, Botanicals & Other Products. Memorial Sloan–Kettering Cancer Center. 8. 12. 2009.
^ Chinnery P, Majamaa K, Turnbull D, Thorburn D (2006). „Treatment for mitochondrial disorders”. Cochrane Database of Systematic Reviews (Online) (1): CD004426. PMID 16437486. doi:10.1002/14651858.CD004426.pub2.
^ Bolman WM, Richmond JA (1999). „A double-blind, placebo-controlled, crossover pilot trial of low-dose dimethylglycine in patients with autistic disorder”. Journal of Autism and Developmental Disorders. 29 (3): 191—4. PMID 10425581.
^ Kern JK, Miller VS, Cauller PL, Kendall PR, Mehta PJ, Dodd M (2001). „Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder”. Journal of Child Neurology. 16 (3): 169—73. PMID 11305684. Архивирано из оригинала 10. 07. 2012. г. Приступљено 30. 10. 2012.

[1] „dimethylglycine - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 16. 9. 2004. Identification. Приступљено 24. 4. 2012.

[2] Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[3] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[4] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[5] „Dimethylglycine”. About Herbs, Botanicals & Other Products. Memorial Sloan–Kettering Cancer Center. 8. 12. 2009.

[Chinnery2006-6] Chinnery P, Majamaa K, Turnbull D, Thorburn D (2006). „Treatment for mitochondrial disorders”. Cochrane Database of Systematic Reviews (Online) (1): CD004426. PMID 16437486. doi:10.1002/14651858.CD004426.pub2.

[7] Bolman WM, Richmond JA (1999). „A double-blind, placebo-controlled, crossover pilot trial of low-dose dimethylglycine in patients with autistic disorder”. Journal of Autism and Developmental Disorders. 29 (3): 191—4. PMID 10425581.

[8] Kern JK, Miller VS, Cauller PL, Kendall PR, Mehta PJ, Dodd M (2001). „Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder”. Journal of Child Neurology. 16 (3): 169—73. PMID 11305684. Архивирано из оригинала 10. 07. 2012. г. Приступљено 30. 10. 2012.

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