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Estron je organsko jedinjenje, koje sadrži 18 atoma ugljenika i ima molekulsku masu od 270,366 Da.[1][2][3][4]

Estron
Estron.svg
Estrona3D.png
Klinički podaci
Prodajno imeAquacrine, Crinovaryl, Cristallovar, Crystogen
Drugs.comMonografija
Način primeneIntravaginalno, oralno
Farmakokinetički podaci
Poluvreme eliminacije19 h
Identifikatori
CAS broj53-16-7 ДаY
ATC kodG03CA07 (WHO), G03CC04
PubChemCID 5870
IUPHAR/BPS2818
DrugBankDB00655 ДаY
ChemSpider5660 ДаY
KEGGC00468 ДаY
ChEBICHEBI:17263 ДаY
ChEMBLCHEMBL1405 ДаY
Hemijski podaci
FormulaC18H22O2
Molarna masa270,366
Fizički podaci
Tačka topljenja2.602 °C (4.716 °F)
Tačka ključanja154 °C (309 °F)

OsobineУреди

ReferenceУреди

  1. ^ Miyoshi Y, Tanji Y, Taguchi T, Tamaki Y, Noguchi S: Association of serum estrone levels with estrogen receptor-positive breast cancer risk in postmenopausal Japanese women. Clin Cancer Res. 2003 Jun;9(6):2229-33. PMID 12796390
  2. ^ Kajta M, Lason W, Bien E, Marszal M: Neuroprotective effects of estrone on NMDA-induced toxicity in primary cultures of rat cortical neurons are independent of estrogen receptors. Pol J Pharmacol. 2002 Nov-Dec;54(6):727-9. PMID 12866733
  3. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.  уреди
  4. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.  уреди
  5. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  6. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.  уреди
  7. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.  уреди

LiteraturaУреди

Spoljašnje vezeУреди

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