Hidromorfon
Hidromorfon je organsko jedinjenje, koje sadrži 17 atoma ugljenika i ima molekulsku masu od 285,338 Da.[1][2][3][4]
Klinički podaci | |
---|---|
Prodajno ime | Dilaudid, Dilaudid Oros, Dilaudid-hp, DiMo |
Drugs.com | Monografija |
Način primene | Oralno, intramaskularno, intravenozno |
Farmakokinetički podaci | |
Poluvreme eliminacije | 2,6 h |
Izlučivanje | Renalno |
Identifikatori | |
CAS broj | 466-99-9 |
ATC kod | N02AA03 (WHO) |
PubChem | CID 5284570 |
DrugBank | DB00327 |
ChemSpider | 4447624 |
KEGG | C07042 |
ChEBI | CHEBI:5790 |
ChEMBL | CHEMBL398707 |
Hemijski podaci | |
Formula | C17H19NO3 |
Molarna masa | 285,338 |
| |
| |
Fizički podaci | |
Tačka topljenja | 2.665 °C (4.829 °F) |
Osobine
уредиOsobina | Vrednost |
---|---|
Broj akceptora vodonika | 4 |
Broj donora vodonika | 1 |
Broj rotacionih veza | 0 |
Particioni koeficijent[5] (ALogP) | 1,7 |
Rastvorljivost[6] (logS, log(mol/L)) | -2,0 |
Polarna površina[7] (PSA, Å2) | 49,8 |
Reference
уреди- ^ Coda BA, Rudy AC, Archer SM, Wermeling DP: Pharmacokinetics and bioavailability of single-dose intranasal hydromorphone hydrochloride in healthy volunteers. Anesth Analg. 2003 Jul;97(1):117-23, table of contents. PMID 12818953
- ^ Vallner JJ, Stewart JT, Kotzan JA, Kirsten EB, Honigberg IL: Pharmacokinetics and bioavailability of hydromorphone following intravenous and oral administration to human subjects. J Clin Pharmacol. 1981 Apr;21(4):152-6. PMID 6165742
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
уреди- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
уреди
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