Hidromorfon je organsko jedinjenje, koje sadrži 17 atoma ugljenika i ima molekulsku masu od 285,338 Da.[1][2][3][4]

Hidromorfon
Klinički podaci
Prodajno imeDilaudid, Dilaudid Oros, Dilaudid-hp, DiMo
Drugs.comMonografija
Način primeneOralno, intramaskularno, intravenozno
Farmakokinetički podaci
Poluvreme eliminacije2,6 h
IzlučivanjeRenalno
Identifikatori
CAS broj466-99-9 ДаY
ATC kodN02AA03 (WHO)
PubChemCID 5284570
DrugBankDB00327 ДаY
ChemSpider4447624 ДаY
KEGGC07042 ДаY
ChEBICHEBI:5790 ДаY
ChEMBLCHEMBL398707 ДаY
Hemijski podaci
FormulaC17H19NO3
Molarna masa285,338
  • [H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1([H])CCC2=O
  • InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1 ДаY
  • Key:WVLOADHCBXTIJK-YNHQPCIGSA-N ДаY
Fizički podaci
Tačka topljenja2.665 °C (4.829 °F)
Osobina Vrednost
Broj akceptora vodonika 4
Broj donora vodonika 1
Broj rotacionih veza 0
Particioni koeficijent[5] (ALogP) 1,7
Rastvorljivost[6] (logS, log(mol/L)) -2,0
Polarna površina[7] (PSA, Å2) 49,8

Reference

уреди
  1. ^ Coda BA, Rudy AC, Archer SM, Wermeling DP: Pharmacokinetics and bioavailability of single-dose intranasal hydromorphone hydrochloride in healthy volunteers. Anesth Analg. 2003 Jul;97(1):117-23, table of contents. PMID 12818953
  2. ^ Vallner JJ, Stewart JT, Kotzan JA, Kirsten EB, Honigberg IL: Pharmacokinetics and bioavailability of hydromorphone following intravenous and oral administration to human subjects. J Clin Pharmacol. 1981 Apr;21(4):152-6. PMID 6165742
  3. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126. 
  4. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. 
  5. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  6. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  7. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

уреди

Spoljašnje veze

уреди


 Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).