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Hloramfenikol je organsko jedinjenje, koje sadrži 11 atoma ugljenika i ima molekulsku masu od 323,129 Da.[1][2][3][4][5][6][7]

Hloramfenikol
Chloramphenicol-2D-skeletal.svg
Chloramphenicol-3D-vdW.png
Klinički podaci
Prodajno imeAk-chlor, Ak-Chlor Ophthalmic Ointment, Ak-Chlor Ophthalmic Solution, Alficetyn
Drugs.comMonografija
Način primeneOftalmički, intramaskularno
Farmakokinetički podaci
Poluvreme eliminacije1,5 - 3,5 h
Identifikatori
CAS broj56-75-7 ДаY
ATC kodD06AX02 (WHO), S03AA08
PubChemCID 298
DrugBankDB00446 ДаY
ChemSpider5744 ДаY
KEGGC00918 ДаY
ChEBICHEBI:17698 ДаY
ChEMBLCHEMBL130 ДаY
Hemijski podaci
FormulaC11H12Cl2N2O5
Molarna masa323,129
Fizički podaci
Tačka topljenja1.505 °C (2.741 °F)

OsobineУреди

ReferenceУреди

  1. ^ Bhutta ZA, Niazi SK, Suria A: Chloramphenicol clearance in typhoid fever: implications for therapy. Indian J Pediatr. 1992 Mar-Apr;59(2):213-9. PMID 1398851
  2. ^ Wali SS, Macfarlane JT, Weir WR, Cleland PG, Ball PA, Hassan-King M, Whittle HC, Greenwood BM: Single injection treatment of meningococcal meningitis. 2. Long-acting chloramphenicol. Trans R Soc Trop Med Hyg. 1979;73(6):698-702. PMID 538813
  3. ^ Puddicombe JB, Wali SS, Greenwood BM: A field trial of a single intramuscular injection of long-acting chloramphenicol in the treatment of meningococcal meningitis. Trans R Soc Trop Med Hyg. 1984;78 (3):399-403. PMID 6464136
  4. ^ Pecoul B, Varaine F, Keita M, Soga G, Djibo A, Soula G, Abdou A, Etienne J, Rey M: Long-acting chloramphenicol versus intravenous ampicillin for treatment of bacterial meningitis. Lancet. 1991 Oct 5; 338(8771):862-6. PMID 1681224
  5. ^ Nathan N, Borel T, Djibo A, Evans D, Djibo S, Corty JF, Guillerm M, Alberti KP, Pinoges L, Guerin PJ, Legros D: Ceftriaxone as effective as long-acting chloramphenicol in short-course treatment of meningococcal meningitis during epidemics: a randomised non-inferiority study. Lancet. 2005 Jul 23-29;366(9482):308-13. PMID 16039333
  6. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126. 
  7. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. 
  8. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  9. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  10. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

LiteraturaУреди

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