Hidroksizin

Hidroksizin
IUPAC ime
	(±)-2-(2-{4-[(4-hlorofenil)-fenilmetil]piperazin-1-il}etoksi)etanol
Klinički podaci
Prodajno ime	Ataraks, Vistaril, drugi
Drugs.com	Монографија
MedlinePlus	a682866
Kategorija trudnoće	AU: A ; US: C (Mogući rizik) ; ;
Način primene	oralno, intramaskularno
Pravni status
Pravni status	AU: S4 (Prescription only) ; ℞ (Prescription only);
Farmakokinetički podaci
Bioraspoloživost	visoka
Vezivanje proteina	93%
Metabolizam	hepati;ki
Metaboliti	Cetirizin, drugi
Poluvreme eliminacije	Odrasli: 20,0 sata; Deca: 7,1 sati
Izlučivanje	Urin, fekalije
Identifikatori
CAS broj	68-88-2 ; 2192-20-3 (dihidrohlorid); 10246-75-0 (pamoat)
ATC kod	N05BB01 (WHO)
PubChem	CID 3658
IUPHAR/BPS	7199
DrugBank	DB00557
ChemSpider	3531
UNII	30S50YM8OG
KEGG	D08054
ChEBI	CHEBI:5818
ChEMBL	CHEMBL896
Sinonimi	UCB-4492
Hemijski podaci
Formula	C21H27ClN2O2
Molarna masa	374.904 g/mol
	SMILES Clc1ccc(cc1)C(c2ccccc2)N3CCN(CC3)CCOCCO; ;
	InChI InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2 ; Key:ZQDWXGKKHFNSQK-UHFFFAOYSA-N ;

Hidroksizin (Vistaril, Ataraks) pripada prvoj generaciji antihistamina difenilmetanske i piperazinske klase. On je prvi put sintetisan 1956. i u prodaji je bio od strane kompanije Pfizer u SAD-u iste godine.^[3] On je još uvek u širokoj upotrebi.

Hemija уреди

Hidroksizin se može sintetisati alkilacijom 1-(4-hlorobenzohidril)piperazina sa 2-(2-hidroksietoksi)etilhloridom:^[4]

Reference уреди

^ ^а ^б Paton DM, Webster DR (1985). „Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines)”. Clin Pharmacokinet. 10 (6): 477—97. PMID 2866055.
^ Simons FE, Simons KJ, Frith EM (januar 1984). „The pharmacokinetics and antihistaminic of the H1 receptor antagonist hydroxyzine”. The Journal of Allergy and Clinical Immunology. 73 (1 Pt 1): 69—75. PMID 6141198. doi:10.1016/0091-6749(84)90486-x.
^ Shorter, Edward (2009). Before Prozac: the troubled history of mood disorders in psychiatry. Oxford [Oxfordshire]: Oxford University Press. ISBN 978-0-19-536874-1.
^ H. Morren, U.S. Patent 2.899.436 (1959); H. Morren, DE 1049383 (1954); H. Morren, DE 1061786 (1954); H. Morren, DE 1068262 (1954); H. Morren, DE 1072624 (1954); H. Morren, DE 1075116 (1954).

Literatura уреди

Shorter, Edward (2009). Before Prozac: the troubled history of mood disorders in psychiatry. Oxford [Oxfordshire]: Oxford University Press. ISBN 978-0-19-536874-1.
Hutcheon, D. E.; D.L. Morris; A. Scriabine (1956). „Cardiovascular action of hydroxyzine (Atarax)”. J Pharmacol Exp Ther. 118 (4): 451—460. PMID 13385806.
Dolan, C. M. (1958). „MANAGEMENT OF EMOTIONAL DISTURBANCES—Use of Hydroxyzine (Atarax®) in General Practice”. Calif Med. 88 (6): 443—444. PMC 1512309  . PMID 13536863.
Pfizer Labs (2004). Vistaril (hydroxyzine pamoate) Capsules and Oral Suspension. United States Food and Drug Administration.
Anderson, Philip O.; Knoben, James E.; Troutman, William G. (2002). Handbook of Clinical Drug Data. McGraw-Hill Medical. ISBN 978-0-07-136362-4.
de Brabander, A.; W. Deberdt (1990). „Effect of Hydroxyzine on Attention and Memory”. Human Psychopharmacology. John Wiley & Sons. 5 (4): 357—362. doi:10.1002/hup.470050408. Приступљено 9. 3. 2007. ^{[мртва веза]}
Clark, B. G.; M. Araki; H. W. Brown (1982). „Hydroxyzine-Associated Tardive Dyskinesia”. Ann Neurol. 11 (4): 435. PMID 7103423. doi:10.1002/ana.410110423.
Porsolt, R. D.; P. Martin; et al. (1989). „Prevention of "Learned Helplessness" in the Rat by Hydroxyzine”. Drug Dev. Res. 17 (3): 227—236. doi:10.1002/ddr.430170306. Приступљено 10. 3. 2007. ^{[мртва веза]}
Alford, C.; N. Rombautt; et al. (1992). „Acute Effects of Hydroxyzine on Nocturnal Sleep and Sleep Tendency the Following Day: a C-EEG Study”. Human Psychopharmacology. 7 (1): 25—35. doi:10.1002/hup.470070104. Приступљено 10. 3. 2007. ^{[мртва веза]}
RxList; et al. (2004). „Atarax Indications, Dosage, Storage, Stability”. RxList - The internet drug index. Архивирано из оригинала 27. 2. 2007. г. Приступљено 9. 3. 2007.
Medscape (2004). „Vistaril Oral: Monograph - Hydroxyzine Hydrochloride, Hydroxyzine Pamoate”. medscape.com. Приступљено 9. 3. 2007.

Spoljašnje veze уреди

U.S. National Library of Medicine: Drug Information Portal - Hydroxyzine

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[pmid2866055-1] а ^б Paton DM, Webster DR (1985). „Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines)”. Clin Pharmacokinet. 10 (6): 477—97. PMID 2866055.

[pmid6141198-2] Simons FE, Simons KJ, Frith EM (januar 1984). „The pharmacokinetics and antihistaminic of the H1 receptor antagonist hydroxyzine”. The Journal of Allergy and Clinical Immunology. 73 (1 Pt 1): 69—75. PMID 6141198. doi:10.1016/0091-6749(84)90486-x.

[isbn0-19-536874-6-3] Shorter, Edward (2009). Before Prozac: the troubled history of mood disorders in psychiatry. Oxford [Oxfordshire]: Oxford University Press. ISBN 978-0-19-536874-1.

[4] H. Morren, U.S. Patent 2.899.436 (1959); H. Morren, DE 1049383 (1954); H. Morren, DE 1061786 (1954); H. Morren, DE 1068262 (1954); H. Morren, DE 1072624 (1954); H. Morren, DE 1075116 (1954).

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