Kandidapepsin
Kandidapepsin (EC 3.4.23.24, Candida albicans aspartinska proteinaza, Candida albicans karboksilna proteinaza, Candida albicans sekretorna kiselinska proteinaza, Candida olea kiselinska proteinaza, Candida aspartinska proteinaza, Candida olea aspartinska proteinaza, Candida albicans aspartinsk proteinaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Kandidapepsin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.23.24 | ||||||||
| CAS broj | 69458-91-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Preferentno razlaganje na karboksilnim ili hidrofobnim aminokiselinama. Ne dolazi do razlaganja Leu15-Tyr, Tyr16-Leu i Phe24-Phe lanaca insulina B. Dolazi do aktivacije tripsinogena, i degradacije keratina
Ova endopeptidaza je prisutna u gljivi Candida albicans.
Reference
уреди- ^ Remold, H., Fasold, H. and Staib, F. (1968). „Purification and characterization of a proteolytic enzyme from Candida albicans”. Biochim. Biophys. Acta. 167: 399—406. PMID 5729955.
- ^ Rüchel, R. (1981). „Properties of a purified proteinase from the yeast Candida albicans”. Biochim. Biophys. Acta. 659: 99—113. PMID 7018586.
- ^ Negi, M., Tsuboi, R., Matsui, T. and Ogawa, H. (1984). „Isolation and characterization of proteinase from Candida albicans: substrate specificity”. J. Invest. Dermatol. 83: 32—36. PMID 6203988.
- ^ Lott, T.J., Page, L.S., Boiron, P., Benson, J. and Reiss, E. (1989). „Nucleotide sequence of the Candida albicans aspartyl proteinase gene”. Nucleic Acids Res. 17: 1779—1779. PMID 2646602.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Candidapepsin на US National Library of Medicine Medical Subject Headings (MeSH)
