Kaspaza-6 (EC 3.4.22.59, CASP-6, apoptotička proteaza Mch-2, Mch2) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

Kaspaza-6
Identifikatori
EC broj3.4.22.59
CAS broj182372-15-2
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum
Neophodno je prisustvo Asp ostatka u P1 poziciji. Preferentno dolazi do razlaganja sekvence Val-Glu-His-Asp-

Kaspaza-6 je efektor/izvršilac kaspaze, kao što su i kaspaza-3 (EC 3.4.22.56) i kaspaza-7 (EC 3.4.22.60).

Reference

уреди
  1. ^ Cowling, V. & Downward, J. (2002). „Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain”. Cell Death Differ. 9: 1046—1056. PMID 12232792. 
  2. ^ Chang, H.Y. & Yang, X. (2000). „Proteases for cell suicide: functions and regulation of caspases”. Microbiol. Mol. Biol. Rev. 64: 821—846. PMID 11104820. 
  3. ^ Kang, B.H., Ko, E., Kwon, O.K. and Choi, K.Y. (2002). „The structure of procaspase 6 is similar to that of active mature caspase 6”. Biochem. J. 364: 629—634. PMID 12049625. 
  4. ^ Lee, S.C., Chan, J., Clement, M.V. and Pervaiz, S. (2006). „Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop”. Proteomics. 6: 2386—2394. PMID 16518869. 
  5. ^ MacLachlan, T.K. & El-Deiry, W.S. (2002). „Apoptotic threshold is lowered by p53 transactivation of caspase-6”. Proc. Natl. Acad. Sci. USA. 99: 9492—9497. PMID 12089322. 
  6. ^ Takahashi, A., Alnemri, E.S., Lazebnik, Y.A., Fernandes-Alnemri, T., Litwack, G., Moir, R.D., Goldman, R.D., Poirier, G.G., Kaufmann, S.H. and Earnshaw, W.C. (1996). „Cleavage of lamin A by Mch2α but not CPP32: multiple interleukin 1β-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis”. Proc. Natl. Acad. Sci. USA. 93: 8395—8400. PMID 8710882. 

Literatura

уреди

Spoljašnje veze

уреди
  • Caspase-6 на US National Library of Medicine Medical Subject Headings (MeSH)