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Kinin (lek) je organsko jedinjenje, koje sadrži 20 atoma ugljenika i ima molekulsku masu od 324,417 Da.[1][2][3]

Kinin (lek)
QuinineBKchemSVG.svg
Quinine-3D-balls.png
Klinički podaci
Prodajno imeAflukin, Chinin, Chinine, Coco-Quinine
Drugs.comMonografija
Način primeneOralno
Farmakokinetički podaci
Poluvreme eliminacije18 h
IzlučivanjeRenalno
Identifikatori
CAS broj130-95-0 ДаY
ATC kodM09AA01 (WHO), P01BC01
PubChemCID 8549
IUPHAR/BPS2510
DrugBankDB00468 ДаY
ChemSpider84989 ДаY
KEGGC06526 ДаY
ChEBICHEBI:15854 ДаY
ChEMBLCHEMBL170 ДаY
Hemijski podaci
FormulaC20H24N2O2
Molarna masa324,417
Fizički podaci
Tačka topljenja57 °C (135 °F)

Садржај

OsobineУреди

ReferenceУреди

  1. ^ Paintaud G, Alvan G, Berninger E, Gustafsson LL, Idrizbegovic E, Karlsson KK, Wakelkamp M: The concentration-effect relationship of quinine-induced hearing impairment. Clin Pharmacol Ther. 1994 Mar;55(3):317-23. PMID 8143397
  2. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126. 
  3. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. 
  4. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  5. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  6. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

LiteraturaУреди

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