Matrilizin (EC 3.4.24.23, matrin, uterinska metaloendopeptidaza, matriks metaloproteinaza 7, matriks metaloproteinazna pumpa 1, MMP 7, PUMP-1 proteinaza, PUMP, metaloproteinazna pumpa-1, MMP) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Matrilizin
Identifikatori
EC broj3.4.24.23
CAS broj141256-52-2
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBsum
Razlaganje Ala14-Leu i Tyr16-Leu u B lancu insulina. Ne dolazi do razlaganja kolagenskih tipova I, II, IV, V. Razlaže se želatinski lanac alfa2(I) > alfa1(I)

Ovaj enzim je prisutan u materici pacova.

ReferenceУреди

  1. ^ Muller, D., Quantin, B., Gesnel, M.-C., Millon-Collard, R., Abecassis, J. and Breathnach, R. (1988). „The collagenase gene family in humans consists of at least four members”. Biochem. J. 253: 187—192. PMID 2844164. 
  2. ^ Woessner, J.F., Jr. & Taplin, C.J. (1988). „Purification and properties of a small latent matrix metalloproteinase of the rat uterus”. J. Biol. Chem. 263: 16918—16925. PMID 3182822. 
  3. ^ Quantin, B., Murphy, G. and Breathnach, R. (1989). „Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members”. Biochemistry. 28: 5327—5334. PMID 2550050. 
  4. ^ Miyazaki, K., Hattori, Y., Umenishi, F., Yasumitsu, H. and Umeda, M. (1990). „Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line”. Cancer Res. 50: 7758—7764. PMID 2253219. 

LiteraturaУреди

Spoljašnje vezeУреди

  • Matrilysin на US National Library of Medicine Medical Subject Headings (MeSH)