4-Hidroksibenzoat nonapreniltransferaza
(преусмерено са P-hidroksibenzoat polipreniltransferaza)
4-Hidroksibenzoat nonapreniltransferaza (EC 2.5.1.39, nonaprenil-4-hidroksibenzoat transferaza, 4-hidroksibenzoat transferaza, p-hidroksibenzoat dimetilaliltransferaza, p-hidroksibenzoat polipreniltransferaza, p-hidroksibenzojeva kiselina-poliprenil transferaza, p-hidroksibenzojeva-poliprenil transferaza) je enzim sa sistematskim imenom poliprenil-difosfat:4-hidroksibenzoat polipreniltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 4-Hidroksibenzoat nonapreniltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.39 | ||||||||
| CAS broj | 9030-77-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- poliprenil difosfat + 4-hidroksibenzoat difosfat + 4-hidroksi-3-poliprenilbenzoat
Ovaj enzim učestvuje u biosintezi ubihinona.
Reference
уреди- ^ Kalén, A., Appelkvist, E.-L., Chojnacki, T. and Dallner, G. (1990). „Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver”. J. Biol. Chem. 265: 1158—1164. PMID 2295606.
- ^ Melzer, M. & Heide, L. (1994). „Characterization of polyprenyldiphosphate: 4-hydroxybenzoate polyprenyltransferase from Escherichia coli”. Biochim. Biophys. Acta. 1212: 93—102. PMID 8155731.
- ^ Okada, K., Ohara, K., Yazaki, K., Nozaki, K., Uchida, N., Kawamukai, M., Nojiri, H. and Yamane, H. (2004). „The AtPPT1 gene encoding 4-hydroxybenzoate polyprenyl diphosphate transferase in ubiquinone biosynthesis is required for embryo development in Arabidopsis thaliana”. Plant Mol. Biol. 55: 567—577. PMID 15604701.
- ^ Forsgren, M., Attersand, A., Lake, S., Grunler, J., Swiezewska, E., Dallner, G. and Climent, I. (2004). „Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ”. Biochem. J. 382: 519—526. PMID 15153069.
- ^ Tran, U.C. & Clarke, C.F. (2007). „Endogenous synthesis of coenzyme Q in eukaryotes”. Mitochondrion. 7 Suppl: S62—S71. PMID 17482885.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- 4-hydroxybenzoate+polyprenyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
