Protein O-GlcNAc transferaza
Protein O-GlcNAc transferaza (EC 2.4.1.255, O-GlcNAc transferaza, OGTase, O-vezana N-acetilglukozaminiltransferaza, uridin difosfo-N-acetilglukozamin:polipeptid beta-N-acetilglukozaminiltransferaza, protein O-vezani beta-N-acetilglukozamin transferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:protein-O-beta-N-acetil-D-glukozaminil transferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Protein O-GlcNAc transferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.255 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) UDP-N-acetil-D-glukozamin + [protein]-L-serin UDP + [protein]-3-O-(N-acetil-D-glukozaminil)-L-serin
- (2) UDP-N-acetil-D-glukozamin + [protein]-L-treonin UDP + [protein]-3-O-(N-acetil-D-glukozaminil)-L-treonin
Kod viših eukariota posttranslaciona modifikacija proteinskih serina/treonina N-acetilglukozaminom (O-GlcNAc) je dinamička, induktivna i obilna.
Reference уреди
- ^ Banerjee, S., Robbins, P.W. and Samuelson, J. (2009). „Molecular characterization of nucleocytosolic O-GlcNAc transferases of Giardia lamblia and Cryptosporidium parvum”. Glycobiology. 19: 331—336. PMID 18948359.
- ^ Clarke, A.J., Hurtado-Guerrero, R., Pathak, S., Schuttelkopf, A.W., Borodkin, V., Shepherd, S.M., Ibrahim, A.F. and van Aalten, D.M. (2008). „Structural insights into mechanism and specificity of O-GlcNAc transferase”. EMBO J. 27: 2780—2788. PMID 18818698.
- ^ Rao, F.V., Dorfmueller, H.C., Villa, F., Allwood, M., Eggleston, I.M. and van Aalten, D.M. (2006). „Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis”. EMBO J. 25: 1569—1578. PMID 16541109.
- ^ Haltiwanger, R.S., Blomberg, M.A. and Hart, G.W. (1992). „Glycosylation of nuclear and cytoplasmic proteins. Purification and characterization of a uridine diphospho-N-acetylglucosamine:polypeptide β-N-acetylglucosaminyltransferase”. J. Biol. Chem. 267: 9005—9013. PMID 1533623.
- ^ Lubas, W.A., Frank, D.W., Krause, M. and Hanover, J.A. (1997). „O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats”. J. Biol. Chem. 272: 9316—9324. PMID 9083068.
- ^ Lazarus, M.B., Nam, Y., Jiang, J., Sliz, P. and Walker, S. (2011). „Structure of human O-GlcNAc transferase and its complex with a peptide substrate”. Nature. 469: 564—567. PMID 21240259.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Protein+O-GlcNAc+transferase на US National Library of Medicine Medical Subject Headings (MeSH)
